FMR1-AS1 gene

From WikiProjectMed
Jump to navigation Jump to search
FMR1-AS1
Identifiers
AliasesFMR1-AS1, ASFMR1, FMR1-AS, FMR1AS, FMR4, FMR1-AS1 gene, FMR1 antisense RNA 1, FMR1 antisense RNA 1 (head to head)
External IDsOMIM: 300805 GeneCards: FMR1-AS1
Orthologs
SpeciesHumanMouse
Entrez

100126270

n/a

Ensembl

ENSG00000268066

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr X: 147.91 – 147.91 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene.[3] Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fragile X syndrome.[3][4] FMR1-AS1 has an anti-apoptotic function.[4]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268066 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, et al. (2007). "An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals". Hum Mol Genet. 16 (24): 3174–3187. doi:10.1093/hmg/ddm293. PMID 17921506.
  4. ^ a b Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C (2008). "A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome". PLOS ONE. 3 (1): e1486. Bibcode:2008PLoSO...3.1486K. doi:10.1371/journal.pone.0001486. PMC 2194623. PMID 18213394. Open access icon
Retrieved from "https://mdwiki.org/wiki/FMR1-AS1_gene"