Ets variant 3

ETV3
Identifiers
Aliases	ETV3, METS, PE-1, PE1, bA110J1.4, ETS variant 3, ETS variant transcription factor 3
External IDs	OMIM: 164873 MGI: 1350926 HomoloGene: 21085 GeneCards: ETV3
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.1 Start 157,121,191 bp End 157,138,474 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 87,432,714 bp End 87,447,463 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa palpebral conjunctiva corpus epididymis amniotic fluid pancreatic epithelial cell caput epididymis parietal pleura lactiferous duct vulva oral cavity Top expressed in hair follicle skin of back left colon olfactory epithelium subcutaneous adipose tissue left lung lobe cumulus cell intestinal villus ascending aorta jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DEAD/H-box RNA helicase binding DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific molecular function DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component RNA polymerase II transcription repressor complex transcription repressor complex nucleus Biological process regulation of transcription by RNA polymerase II cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II cellular response to granulocyte macrophage colony-stimulating factor stimulus transcription, DNA-templated negative regulation of cell population proliferation biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2117 27049 Ensembl ENSG00000117036 ENSMUSG00000003382 UniProt P41162 Q8R4Z4 RefSeq (mRNA) NM_001145312 NM_005240 NM_001083318 NM_001286844 NM_012051 NM_001359750 RefSeq (protein) NP_001138784 NP_005231 NP_001076787 NP_001273773 NP_036181 NP_001346679 Location (UCSC) Chr 1: 157.12 – 157.14 Mb Chr 3: 87.43 – 87.45 Mb PubMed search
Wikidata
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Ets variant 3 is a protein that in humans is encoded by the ETV3 gene.

Further reading

• Klemsz M, Hromas R, Raskind W, Bruno E, Hoffman R (March 1994). "PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23". Genomics. 20 (2): 291–4. doi:10.1006/geno.1994.1169. PMID 8020980.
• Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass CK (July 2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS". Cell Cycle. 6 (13): 1594–604. doi:10.4161/cc.6.13.4336. PMID 17525531.
• Anney RJ, Lasky-Su J, O'Dúshláine C, Kenny E, Neale BM, Mulligan A, Franke B, Zhou K, Chen W, Christiansen H, Arias-Vásquez A, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H, Asherson P, Faraone SV, Gill M (December 2008). "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (8): 1369–78. doi:10.1002/ajmg.b.30871. PMID 18951430. S2CID 30325260.
• Sawka-Verhelle D, Escoubet-Lozach L, Fong AL, Hester KD, Herzig S, Lebrun P, Glass CK (April 2004). "PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation". The Journal of Biological Chemistry. 279 (17): 17772–84. doi:10.1074/jbc.M311991200. PMID 14754893.
• Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK (April 2002). "An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation". Cell. 109 (2): 169–80. doi:10.1016/S0092-8674(02)00714-6. PMID 12007404. S2CID 16359491.
• Mesquita B, Lopes P, Rodrigues A, Pereira D, Afonso M, Leal C, Henrique R, Lind GE, Jerónimo C, Lothe RA, Teixeira MR (February 2013). "Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes". Breast Cancer Research and Treatment. 138 (1): 37–45. doi:10.1007/s10549-013-2408-2. PMID 23329352. S2CID 23604624.
• El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Panopolous A, Watowich SS, Häcker H, Foxwell BM, Murray PJ (December 2007). "Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway". Journal of Immunology. 179 (11): 7215–9. doi:10.4049/jimmunol.179.11.7215. PMID 18025162.