Elmo domain containing 2

ELMOD2
Identifiers
Aliases	ELMOD2, 9830169G11Rik, ELMO domain containing 2
External IDs	OMIM: 610196 MGI: 2445165 HomoloGene: 16662 GeneCards: ELMOD2
Gene location (Human) Chr. Chromosome 4 (human) Band 4q31.1 Start 140,524,168 bp End 140,553,770 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C2 Start 84,039,261 bp End 84,059,115 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon renal medulla spinal ganglia cardia trigeminal ganglion jejunal mucosa external globus pallidus vena cava superior surface of tongue corpus callosum Top expressed in secondary oocyte otolith organ utricle hand retinal pigment epithelium medullary collecting duct molar cumulus cell medial ganglionic eminence foot More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity Cellular component membrane Biological process defense response to virus regulation of defense response to virus positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 255520 244548 Ensembl ENSG00000179387 ENSMUSG00000035151 UniProt Q8IZ81 Q8BGF6 RefSeq (mRNA) NM_153702 NM_001170691 NM_178736 RefSeq (protein) NP_714913 NP_001164162 NP_848851 Location (UCSC) Chr 4: 140.52 – 140.55 Mb Chr 8: 84.04 – 84.06 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

ELMO domain containing 2 is a protein that in humans is encoded by the ELMOD2 gene.

Function

This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis.

Further reading

• Hodgson U, Pulkkinen V, Dixon M, Peyrard-Janvid M, Rehn M, Lahermo P, Ollikainen V, Salmenkivi K, Kinnula V, Kere J, Tukiainen P, Laitinen T (2006). "ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis". Am. J. Hum. Genet. 79 (1): 149–54. doi:10.1086/504639. PMC 1474126. PMID 16773575.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.