EDIL3

EDIL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D90
Identifiers
Aliases	EDIL3, DEL1, EGF like repeats and discoidin domains 3
External IDs	OMIM: 606018 MGI: 1329025 HomoloGene: 21166 GeneCards: EDIL3
Gene location (Human) Chr. Chromosome 5 (human) Band 5q14.3 Start 83,940,554 bp End 84,384,880 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 C3 Start 88,969,591 bp End 89,471,342 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus inferior ganglion of vagus nerve subthalamic nucleus tibia superior vestibular nucleus pons ventral tegmental area internal globus pallidus postcentral gyrus trigeminal ganglion Top expressed in lateral geniculate nucleus medial geniculate nucleus medial dorsal nucleus anterior horn of spinal cord globus pallidus calvaria ventral tegmental area lateral hypothalamus suprachiasmatic nucleus dorsomedial hypothalamic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding integrin binding metal ion binding extracellular matrix structural constituent Cellular component extracellular vesicle extracellular region extracellular exosome extracellular matrix collagen-containing extracellular matrix Biological process multicellular organism development cell adhesion positive regulation of cell-substrate adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10085 13612 Ensembl ENSG00000164176 ENSMUSG00000034488 UniProt O43854 O35474 RefSeq (mRNA) NM_001278642 NM_005711 NM_001037987 NM_010103 RefSeq (protein) NP_001265571 NP_005702 NP_001033076 NP_034233 Location (UCSC) Chr 5: 83.94 – 84.38 Mb Chr 13: 88.97 – 89.47 Mb PubMed search
Wikidata
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EGF like repeats and discoidin domains 3 is a protein that in humans is encoded by the EDIL3 gene.

Function

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.

Further reading

• Rezaee M, Penta K, Quertermous T (2002). "Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)". Am. J. Physiol. Heart Circ. Physiol. 282 (5): H1924–32. doi:10.1152/ajpheart.00921.2001. PMID 11959660.
• Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T (2002). "The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation". Microvascular Research. 64 (1): 148–61. doi:10.1006/mvre.2002.2414. PMID 12074641.
• Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur. J. Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124. S2CID 1825380.
• Zou X, Qiao H, Jiang X, Dong X, Jiang H, Sun X (2009). "Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer". J. Biomed. Sci. 16 (1): 33. doi:10.1186/1423-0127-16-33. PMC 2666667. PMID 19292890.
• Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK (2009). "The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations". Hum. Genet. 126 (5): 655–66. doi:10.1007/s00439-009-0714-x. PMC 2783187. PMID 19578876.
• Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB (2010). "Chemerin, a novel adipokine in the regulation of angiogenesis". J. Clin. Endocrinol. Metab. 95 (5): 2476–85. doi:10.1210/jc.2010-0042. PMC 2869547. PMID 20237162.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC (2010). "High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients". World J. Gastroenterol. 16 (36): 4611–5. doi:10.3748/wjg.v16.i36.4611. PMC 2945496. PMID 20857535.
• Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF (2010). "A genome-wide study reveals copy number variants exclusive to childhood obesity cases". Am. J. Hum. Genet. 87 (5): 661–6. doi:10.1016/j.ajhg.2010.09.014. PMC 2978976. PMID 20950786.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.