E-site
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The E-site is the third and final binding site for t-RNA in the ribosome during translation, a part of protein synthesis.[1] The "E" stands for exit, and is accompanied by the P-site (for peptidyl) which is the second binding site, and the A-site (aminoacyl), which is the first binding site. It is involved in cellular processes. [2][3]
References
- ^ Chen, C.; Stevens, B.; Kaur, J.; Smilansky, Z.; Cooperman, B. S.; Goldman, Y. E. (2011-10-03). "Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis". Proceedings of the National Academy of Sciences. 108 (41): 16980–16985. Bibcode:2011PNAS..10816980C. doi:10.1073/pnas.1106999108. ISSN 0027-8424. PMC 3193197. PMID 21969541.
- ^ Kirillov, S., Makarov, E., & Semenkov, Y. (1983). Quantitative study of interaction of deacylated tRNA with Escherichia coli ribosomes. FEBS Letters, 157(1), 91-94. doi:10.1016/0014-5793(83)81122-3
- ^ dx.doi.org. doi:10.17658/issn.2058-5462/issue-23/efisher/p1 http://dx.doi.org/10.17658/issn.2058-5462/issue-23/efisher/p1. Retrieved 2024-01-26.
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- Sergiev, Petr V.; Lesnyak, Dmitry V.; Kiparisov, Sergey V.; Burakovsky, Dmitry E.; Leonov, Andrei A.; Bogdanov, Alexey A.; Brimacombe, Richard; Dontsova, Olga A. (2005). "Function of the ribosomal E-site: a mutagenesis study". Nucleic Acids Research. 33 (18): 6048–6056. doi:10.1093/nar/gki910. ISSN 0305-1048. PMC 1266066. PMID 16243787.
- Chen, Chunlai; Stevens, Benjamin; Kaur, Jaskiran; Smilansky, Zeev; Cooperman, Barry S.; Goldman, Yale E. (2011-10-11). "Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis". Proceedings of the National Academy of Sciences. 108 (41): 16980–16985. Bibcode:2011PNAS..10816980C. doi:10.1073/pnas.1106999108. ISSN 0027-8424. PMC 3193197. PMID 21969541.
- Molecular Biology of the Gene, 7th Edition, James D. Watson, Tania A. Baker,Stephen P. Bell,Alexander Gann, Michael Levine,Richard Losick, ©2014 Pearson
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