Draft:Gary J. Pielak

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  • Comment: Sadly, no source covers the Subject, rather what (he/) worked on (protein biophysics) ANUwrites 18:26, 13 March 2024 (UTC)



Gary J. Pielak (born July 17, 1955) is an American biological chemist, who is known for pioneering quantitative techniques for measuring protein structure, stability, diffusion, and concentration in living cells, and under crowded conditions.

Pielak is the Kenan Distinguished Professor[1] of Chemistry, Biochemistry and Biophysics at the University of North Carolina at Chapel Hill School of Medicine[2], Lineberger Comprehensive Cancer Center[3], and Department of Chemistry[4]. He is a Fellow of the Biophysical Society[5][6].

Education

Pielak earned a BA in Chemistry, cum laude, from Bradley University in 1977, and a Ph.D. in Biochemistry 1983 from Washington State University. He joined the Department of Chemistry at the University of North Carolina at Chapel Hill in 1989.

Research

Using in-cell nuclear magnetic resonance spectroscopy, a technique he helped develop, Pielak's work changed the understanding that the effects of in-cell crowding arise solely from the close packed nature of the cytoplasm. Instead, his work shows that repulsive and attractive chemical interactions between cellular components determine the effects of macromolecular crowding. These interactions organize the inside of cells, controlling metabolism and signaling. He and his collaborators have recently presented a quantitative model to explain crowding effects that is independent of crowder identity.[7] His research reveals the true consequences of the cellular environment on proteins and creates new opportunities for physiologically relevant biophysics.[8][9][10] For his work in this area, he received an NIH Director's Pioneer Award in 2006[11].

Selected Honors

Gary Pielak has been on the Editorial Advisory Board of the journal Protein Science, and serves on the Editorial Board of the journal Magnetic Resonance Letters[12]. He was an Invited Speaker at the 2017 Nobel Symposium on Protein Folding: From Mechanisms to Impact on Cells, in Stockholm, Sweden.[13][14] Pielak was the Plenary Lecture speaker at the 2021 EUROMAR, conference, in Portorož, Slovenia.

In 2022 he was an invited speaker at Specificity Determinants of Biomolecular Interactions, commemorating the late professor Aharon Katzir, in Rehovot Israel, and was an invited speaker at the German Biophysical Society Meeting, in Konstanz, Germany. In 2023, Pielak received both the Johnston Teaching Excellence Award and the Faculty Award for Excellence in Doctoral Mentoring from the University of North Carolina at Chapel Hill. He also presented the McElvian Lecture at the University of Wisconsin, Madison, that year. In 2024, he was the invited speaker, at Protein Folding Dynamics Gordon Research Conference in Galveston, Texas.

Most Highly Cited Publications

Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs), Francois-Xavier Theillet, Andres Binolfi, Tamara Frembgen-Kesner, Karan Hingorani, Mohona Sarkar, Ciara Kyne, Conggang Li, Peter B Crowley, Lila Gierasch, Gary J Pielak, Adrian H Elcock, Anne Gershenson, Philipp Selenko, Chemical Reviews 114 (13), 6661-6714[15]

FlgM gains structure in living cells, Matthew M Dedmon, Chetan N Patel, Gregory B Young, Gary J Pielak, Proceedings of the National Academy of Sciences 99 (20), 12681-12684[16]

Impact of Protein Denaturants and Stabilizers on Water Structure, Joseph D. Batchelor, Alina Olteanu, Ashutosh Tripathy, and Gary J. Pielak, J. Am. Chem. Soc. 2004, 126, 7, 1958–1961[17]

Macromolecular Crowding and Protein Stability, Yaqiang Wang, Mohona Sarkar, Austin E. Smith, Alexander S. Krois, and Gary J. Pielak, J. Am. Chem. Soc. 2012, 134, 40, 16614–16618[18]

References

  1. ^ "University Distinguished Professors". Provost & Chief Academic Officer - UNC Chapel Hill. Retrieved 2024-03-21.
  2. ^ "Gary Pielak". Biochemistry and Biophysics. Retrieved 2024-04-09.
  3. ^ "Gary Pielak". UNC Lineberger. Retrieved 2024-04-09.
  4. ^ "Pielak, Gary". Retrieved 2024-04-09.
  5. ^ Clabo, Carolyn (2023-09-22). "Dr. Gary Pielak named 2024 Biophysical Society Fellow". Biochemistry and Biophysics. Retrieved 2024-03-21.
  6. ^ "Pielak elected 2024 Biophysical Society Fellow". Retrieved 2024-04-09.
  7. ^ Stewart, Claire J.; Olgenblum, Gil I.; Propst, Ashlee; Harries, Daniel; Pielak, Gary J. (2023-01-23) [January 23, 2023]. "Resolving the enthalpy of protein stabilization by macromolecular crowding". Protein Science. 32 (3): e4573. doi:10.1002/pro.4573. ISSN 0961-8368. PMC 9942490. PMID 36691735.
  8. ^ Guseman, Alex J.; Pielak, Gary J. (2019), Ito, Yutaka; Dötsch, Volker; Shirakawa, Masahiro (eds.), "Chapter 12. Protein Stability and Weak Intracellular Interactions", New Developments in NMR, Cambridge: Royal Society of Chemistry, pp. 188–206, doi:10.1039/9781788013079-00188, ISBN 978-1-78801-217-1, S2CID 213364320, retrieved 2024-03-13
  9. ^ Pielak, Gary (March 1, 2021). "Dynamical spectroscopy and microscopy of proteins in cells". Current Opinion in Structural Biology. 70: 1–7. doi:10.1016/j.sbi.2021.02.001. PMID 33662744 – via Elsevier Science Direct.
  10. ^ Speer, Shannon L.; Stewart, Claire J.; Sapir, Liel; Harries, Daniel; Pielak, Gary J. (2022-05-09). "Macromolecular Crowding Is More than Hard-Core Repulsions". Annual Review of Biophysics. 51 (1): 267–300. doi:10.1146/annurev-biophys-091321-071829. ISSN 1936-122X. PMID 35239418.
  11. ^ "2006 Awardees | NIH Common Fund". commonfund.nih.gov. Retrieved 2024-03-21.
  12. ^ https://www.sciencedirect.com/journal/magnetic-resonance-letters/about/editorial-board
  13. ^ "Protein folding: Much more intricate than we thought". Chemical & Engineering News. Retrieved 2024-03-13.
  14. ^ Kostic, Milka. "Nobel Symposium on Protein Folding: Thoughts, impressions, and zingers". crosstalk.cell.com. Retrieved 2024-03-13.
  15. ^ Theillet, Francois-Xavier; Binolfi, Andres; Frembgen-Kesner, Tamara; Hingorani, Karan; Sarkar, Mohona; Kyne, Ciara; Li, Conggang; Crowley, Peter B.; Gierasch, Lila; Pielak, Gary J.; Elcock, Adrian H.; Gershenson, Anne; Selenko, Philipp (2014-07-09). "Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)". Chemical Reviews. 114 (13): 6661–6714. doi:10.1021/cr400695p. ISSN 0009-2665. PMC 4095937. PMID 24901537.
  16. ^ Dedmon, Matthew M.; Patel, Chetan N.; Young, Gregory B.; Pielak, Gary J. (2002-09-23). "FlgM gains structure in living cells". Proceedings of the National Academy of Sciences. 99 (20): 12681–12684. Bibcode:2002PNAS...9912681D. doi:10.1073/pnas.202331299. ISSN 0027-8424. PMC 130520. PMID 12271132.
  17. ^ Batchelor, Joseph D.; Olteanu, Alina; Tripathy, Ashutosh; Pielak, Gary J. (2004-02-01). "Impact of Protein Denaturants and Stabilizers on Water Structure". Journal of the American Chemical Society. 126 (7): 1958–1961. doi:10.1021/ja039335h. ISSN 0002-7863. PMID 14971928.
  18. ^ Wang, Yaqiang; Sarkar, Mohona; Smith, Austin E.; Krois, Alexander S.; Pielak, Gary J. (2012-10-10). "Macromolecular Crowding and Protein Stability". Journal of the American Chemical Society. 134 (40): 16614–16618. doi:10.1021/ja305300m. ISSN 0002-7863. PMID 22954326.

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