DUSP2

DUSP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M3G
Identifiers
Aliases	DUSP2, PAC-1, PAC1, dual specificity phosphatase 2
External IDs	OMIM: 603068 MGI: 101911 HomoloGene: 3255 GeneCards: DUSP2
Gene location (Human) Chr. Chromosome 2 (human) Band 2q11.2 Start 96,143,169 bp End 96,145,440 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 F1 Start 127,178,079 bp End 127,180,296 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula lymph node mucosa of urinary bladder monocyte spleen gallbladder bone marrow cells appendix skin of abdomen anterior pituitary Top expressed in thymus spleen trachea blood lip bone marrow subcutaneous adipose tissue endocardial cushion atrium hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity mitogen-activated protein kinase binding Cellular component nucleus nuclear membrane cytoplasm Biological process protein dephosphorylation endoderm formation dephosphorylation peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1844 13537 Ensembl ENSG00000158050 ENSMUSG00000027368 UniProt Q05923 Q05922 RefSeq (mRNA) NM_004418 NM_010090 RefSeq (protein) NP_004409 NP_034220 Location (UCSC) Chr 2: 96.14 – 96.15 Mb Chr 2: 127.18 – 127.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

Further reading

• Wu J, Jin YJ, Calaf GM, et al. (2007). "PAC1 is a direct transcription target of E2F-1 in apoptotic signaling". Oncogene. 26 (45): 6526–35. doi:10.1038/sj.onc.1210484. PMID 17471234.
• Zhang Q, Muller M, Chen CH, et al. (2006). "New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding". J. Mol. Biol. 354 (4): 777–88. doi:10.1016/j.jmb.2005.10.006. PMID 16288922.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kothapalli R, Yoder SJ, Kusmartseva I, Loughran TP (2004). "Characterization of a variant of PAC-1 in large granular lymphocyte leukemia". Protein Expr. Purif. 32 (1): 52–60. doi:10.1016/S1046-5928(03)00237-7. PMID 14680939.
• Zhang Y, Guan DL, Xia CQ, et al. (2004). "Relationship between the expression levels of CD61, CD63, and PAC-1 on platelet surface in peripheral blood and the transplanted kidney function". Transplant. Proc. 35 (4): 1360–3. doi:10.1016/S0041-1345(03)00469-X. PMID 12826159.
• Farooq A, Plotnikova O, Chaturvedi G, et al. (2003). "Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP". Structure. 11 (2): 155–64. doi:10.1016/S0969-2126(02)00943-7. PMID 12575935.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ward Y, Gupta S, Jensen P, et al. (1994). "Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1". Nature. 367 (6464): 651–4. Bibcode:1994Natur.367..651W. doi:10.1038/367651a0. PMID 8107850. S2CID 4257340.
• Rohan PJ, Davis P, Moskaluk CA, et al. (1993). "PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase". Science. 259 (5102): 1763–6. Bibcode:1993Sci...259.1763R. doi:10.1126/science.7681221. PMID 7681221.
• Raingeaud J, Gupta S, Rogers JS, et al. (1995). "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine". J. Biol. Chem. 270 (13): 7420–6. doi:10.1074/jbc.270.13.7420. PMID 7535770.