DLG2

DLG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BYG, 2HE2
Identifiers
Aliases	DLG2, PPP1R58, PSD-93, PSD93, chapsyn-110, discs large homolog 2, discs large MAGUK scaffold protein 2
External IDs	OMIM: 603583 MGI: 1344351 HomoloGene: 1046 GeneCards: DLG2
Gene location (Human) Chr. Chromosome 11 (human) Band 11q14.1 Start 83,455,012 bp End 85,627,922 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 E1|7 51.07 cM Start 90,476,672 bp End 92,449,247 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell corpus callosum inferior ganglion of vagus nerve prefrontal cortex entorhinal cortex middle temporal gyrus nucleus accumbens hippocampus proper Brodmann area 23 amygdala Top expressed in superior frontal gyrus piriform cortex olfactory tubercle cerebellar vermis primary motor cortex cingulate gyrus nucleus accumbens lateral hypothalamus supraoptic nucleus subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanylate kinase activity kinase binding protein binding ionotropic glutamate receptor binding structural constituent of postsynaptic density Cellular component postsynaptic membrane cell projection membrane postsynaptic density voltage-gated potassium channel complex plasma membrane synapse axon cell junction basolateral plasma membrane ionotropic glutamate receptor complex juxtaparanode region of axon cytosol neuromuscular junction neuron projection postsynaptic density membrane glutamatergic synapse axon cytoplasm Biological process chemical synaptic transmission receptor localization to synapse negative regulation of phosphatase activity receptor clustering nervous system development establishment or maintenance of epithelial cell apical/basal polarity sensory perception of pain GDP metabolic process GMP metabolic process MAPK cascade cellular response to potassium ion cell-cell adhesion maintenance of postsynaptic density structure anterograde axonal protein transport retrograde axonal protein transport neurotransmitter receptor localization to postsynaptic specialization membrane regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1740 23859 Ensembl ENSG00000150672 ENSMUSG00000052572 UniProt Q15700 Q91XM9 RefSeq (mRNA) NM_001142699 NM_001142700 NM_001142702 NM_001206769 NM_001300983 NM_001364 NM_001351274 NM_001351275 NM_001351276 NM_001377966 NM_001377967 NM_001377968 NM_001377970 NM_001377971 NM_001377972 NM_001377973 NM_001377974 NM_001377975 NM_001377976 NM_001377977 NM_001377978 NM_001377979 NM_001377980 NM_001377981 NM_001377982 NM_001377983 NM_175892 NM_001243046 NM_001243047 NM_011807 RefSeq (protein) NP_001136171 NP_001136172 NP_001136174 NP_001193698 NP_001287912 NP_001355 NP_001338203 NP_001338204 NP_001338205 NP_001364895 NP_001364896 NP_001364897 NP_001364899 NP_001364900 NP_001364901 NP_001364902 NP_001364903 NP_001364904 NP_001364905 NP_001364906 NP_001364907 NP_001364908 NP_001364909 NP_001364910 NP_001364911 NP_001364912 NP_001229975 NP_001229976 NP_035937 Location (UCSC) Chr 11: 83.46 – 85.63 Mb Chr 7: 90.48 – 92.45 Mb PubMed search
Wikidata
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Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.

Function

Chapsyn-110/PSD-93 a member of the membrane-associated guanylate kinase (MAGUK) family. The protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Alternatively spliced transcript variants encoding distinct isoforms have been described but their full-length nature has yet to be completely determined.

Interactions

DLG2 has been shown to interact with GRIN2B, KCNJ12.

Further reading

• Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M (1995). "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases". Nature. 378 (6552): 85–8. Bibcode:1995Natur.378...85K. doi:10.1038/378085a0. PMID 7477295. S2CID 4362906.
• Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS (1996). "Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains". Cell. 84 (5): 757–67. doi:10.1016/S0092-8674(00)81053-3. PMID 8625413. S2CID 15834673.
• Hsueh YP, Kim E, Sheng M (1997). "Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95". Neuron. 18 (5): 803–14. doi:10.1016/S0896-6273(00)80319-0. PMID 9182804. S2CID 18331544.
• Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762. S2CID 16068361.
• Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW (1998). "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit". J. Biol. Chem. 273 (31): 19518–24. doi:10.1074/jbc.273.31.19518. PMID 9677374.
• Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324. S2CID 12465062.
• Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS (1998). "Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A". J. Neurosci. 18 (21): 8805–13. doi:10.1523/JNEUROSCI.18-21-08805.1998. PMC 6793550. PMID 9786987.
• Craven SE, El-Husseini AE, Bredt DS (1999). "Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs". Neuron. 22 (3): 497–509. doi:10.1016/S0896-6273(00)80705-9. PMID 10197530.
• Sans N, Petralia RS, Wang YX, Blahos J, Hell JW, Wenthold RJ (2000). "A developmental change in NMDA receptor-associated proteins at hippocampal synapses". J. Neurosci. 20 (3): 1260–71. doi:10.1523/JNEUROSCI.20-03-01260.2000. PMC 6774158. PMID 10648730.
• Garcia RA, Vasudevan K, Buonanno A (2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3596–601. doi:10.1073/pnas.070042497. PMC 16285. PMID 10725395.
• Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. hdl:1842/742. PMID 10862698. S2CID 14392630.
• Firestein BL, Craven SE, Bredt DS (2001). "Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains". NeuroReport. 11 (16): 3479–84. doi:10.1097/00001756-200011090-00016. PMID 11095503. S2CID 19718975.
• Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T (2001). "The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase". Genes Cells. 5 (11): 905–911. doi:10.1046/j.1365-2443.2000.00374.x. PMID 11122378. S2CID 37107139.
• DeMarco SJ, Strehler EE (2001). "Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins". J. Biol. Chem. 276 (24): 21594–600. doi:10.1074/jbc.M101448200. PMID 11274188.
• Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
• Weitzdoerfer R, Dierssen M, Fountoulakis M, Lubec G (2002). "Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure". Protein Expression in Down Syndrome Brain. pp. 59–70. doi:10.1007/978-3-7091-6262-0_5. ISBN 978-3-211-83704-7. PMID 11771761. {{cite book}}: |journal= ignored (help)