DAZ associated protein 1

DAZAP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2DGS, 2DH8
Identifiers
Aliases	DAZAP1, DAZ associated protein 1
External IDs	OMIM: 607430 HomoloGene: 137331 GeneCards: DAZAP1
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 1,407,569 bp End 1,435,687 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura germinal epithelium trabecular bone tibia skin of abdomen sural nerve amniotic fluid parietal pleura vagina right lobe of thyroid gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA stem-loop binding nucleic acid binding RNA binding protein binding poly(U) RNA binding poly(G) binding mRNA 3'-UTR binding mRNA binding Cellular component nucleus nucleoplasm cytoplasm cytosol ribonucleoprotein complex protein-containing complex Biological process multicellular organism development maternal placenta development cell population proliferation cell differentiation positive regulation of mRNA splicing, via spliceosome spermatogenesis germ cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26528 n/a Ensembl ENSG00000071626 n/a UniProt Q96EP5 n/a RefSeq (mRNA) NM_018959 NM_170711 NM_001352033 NM_001352034 NM_001352035 n/a RefSeq (protein) NP_061832 NP_733829 NP_001338962 NP_001338963 NP_001338964 n/a Location (UCSC) Chr 19: 1.41 – 1.44 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene.

Function

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.

Interactions

DAZ associated protein 1 has been shown to interact with DAZ1.

Further reading

• Dai T, Vera Y, Salido EC, Yen PH (2003). "Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL". BMC Genomics. 2: 6. doi:10.1186/1471-2164-2-6. PMC 57980. PMID 11604102.
• Vera Y, Dai T, Hikim AP, Lue Y, Salido EC, Swerdloff RS, Yen PH (2003). "Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation". J. Androl. 23 (5): 622–8. doi:10.1002/j.1939-4640.2002.tb02303.x. PMID 12185095. S2CID 2486961.
• Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP (2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia". Leukemia. 19 (5): 806–13. doi:10.1038/sj.leu.2403684. PMID 15744350. S2CID 7228479.
• Pan HA, Lin YS, Lee KH, Huang JR, Lin YH, Kuo PL (2006). "Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries". Fertil. Steril. 84 (Suppl 2): 1089–94. doi:10.1016/j.fertnstert.2005.03.075. PMID 16209998.
• Morton S, Yang HT, Moleleki N, Campbell DG, Cohen P, Rousseau S (2006). "Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ". Biochem. J. 399 (2): 265–73. doi:10.1042/BJ20060681. PMC 1609909. PMID 16848763.