Cytokine dependent hematopoietic cell linker

CLNK
Identifiers
Aliases	CLNK, MIST, cytokine dependent hematopoietic cell linker
External IDs	OMIM: 611434 MGI: 1351468 HomoloGene: 8450 GeneCards: CLNK
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.1 Start 10,486,395 bp End 10,684,768 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B3 Start 38,863,805 bp End 39,034,155 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney lymph node renal medulla thymus pharynx corpus epididymis cecum caput epididymis deltoid muscle thymus Top expressed in spermatid duodenum jejunum spermatocyte esophagus placenta kidney blood More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component intracellular anatomical structure Biological process intracellular signal transduction immune response transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116449 27278 Ensembl ENSG00000109684 ENSMUSG00000039315 UniProt Q7Z7G1 Q9QZE2 RefSeq (mRNA) NM_052964 NM_013748 RefSeq (protein) NP_443196 NP_038776 Location (UCSC) Chr 4: 10.49 – 10.68 Mb Chr 5: 38.86 – 39.03 Mb PubMed search
Wikidata
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Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene.

Function

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).

Further reading

• Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O (2009). "Screening for replication of genome-wide SNP associations in sporadic ALS". Eur. J. Hum. Genet. 17 (2): 213–8. doi:10.1038/ejhg.2008.194. PMC 2986065. PMID 18987618.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Jin TB, Ren Y, Shi X, Jiri M, He N, Feng T, Yuan D, Kang L (2015). "Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets". Rheumatol. Int. 35 (7): 1141–7. doi:10.1007/s00296-015-3215-3. PMID 25591661. S2CID 23426576.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.