Cyclin dependent kinase like 1

CDKL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AGU
Identifiers
Aliases	CDKL1, KKIALRE, P42, cyclin dependent kinase like 1
External IDs	OMIM: 603441 MGI: 1918341 HomoloGene: 55805 GeneCards: CDKL1
Gene location (Human) Chr. Chromosome 14 (human) Band 14q21.3 Start 50,326,265 bp End 50,416,461 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C2 Start 69,793,622 bp End 69,838,041 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube Achilles tendon canal of the cervix right lobe of thyroid gland monocyte rectum right lung left lobe of thyroid gland Brodmann area 9 transverse colon Top expressed in kidney spermatid spermatocyte blood visual cortex superior frontal gyrus cerebellar cortex seminiferous tubule renal pelvis substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity Cellular component cytoplasm extracellular exosome nucleus nucleoplasm intracellular membrane-bounded organelle ciliary transition zone Biological process heart development phosphorylation regulation of cell cycle protein phosphorylation regulation of cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8814 71091 Ensembl ENSG00000100490 ENSMUSG00000020990 UniProt Q00532 Q8CEQ0 RefSeq (mRNA) NM_001282236 NM_004196 NM_001367064 NM_001367065 NM_183294 RefSeq (protein) NP_001269165 NP_004187 NP_001353993 NP_001353994 NP_899117 Location (UCSC) Chr 14: 50.33 – 50.42 Mb Chr 12: 69.79 – 69.84 Mb PubMed search
Wikidata
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Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene.

Function

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.