CTNNBL1

CTNNBL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CB8, 4CB9, 4CBA, 4HM9, 4HNM, 4MFU, 4MFV
Identifiers
Aliases	CTNNBL1, C20orf33, NAP, P14L, PP8304, dJ633O20.1, catenin beta like 1, IMD99
External IDs	OMIM: 611537 MGI: 1913892 HomoloGene: 12003 GeneCards: CTNNBL1
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.23 Start 37,693,955 bp End 37,872,129 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H1|2 78.4 cM Start 157,579,321 bp End 157,733,534 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen monocyte ganglionic eminence right lobe of liver left uterine tube body of stomach gastric mucosa left ventricle left coronary artery ascending aorta Top expressed in spermatid saccule spermatocyte otic placode primitive streak seminiferous tubule renal corpuscle medullary collecting duct hair follicle external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding protein binding Cellular component cytoplasm spliceosomal complex membrane nucleus Prp19 complex nucleoplasm Biological process positive regulation of apoptotic process mRNA splicing, via spliceosome mRNA processing somatic diversification of immunoglobulins apoptotic process RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56259 66642 Ensembl ENSG00000132792 ENSMUSG00000027649 UniProt Q8WYA6 Q9CWL8 RefSeq (mRNA) NM_001281495 NM_030877 NM_025680 RefSeq (protein) NP_001268424 NP_110517 NP_079956 Location (UCSC) Chr 20: 37.69 – 37.87 Mb Chr 2: 157.58 – 157.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene.

The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. It is a housekeeping gene.

External links

• Human CTNNBL1 genome location and CTNNBL1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.