CSN2

CSN2
Identifiers
Aliases	CSN2, CASB, casein beta, PDC213
External IDs	OMIM: 115460 MGI: 88541 HomoloGene: 1426 GeneCards: CSN2
Gene location (Human) Chr. Chromosome 4 (human) Band 4q13.3 Start 69,955,256 bp End 69,965,728 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 E1|5 43.56 cM Start 87,840,483 bp End 87,847,489 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus salivary gland minor salivary glands islet of Langerhans smooth muscle tissue placenta urinary bladder muscle of leg gastrocnemius muscle hippocampus proper Top expressed in parotid gland thymus belly cord sexually immature organism epidermis trachea white adipose tissue visual cortex superior frontal gyrus diencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding enzyme inhibitor activity transporter activity cysteine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular space Biological process negative regulation of lactation lactation calcium ion transport negative regulation of cysteine-type endopeptidase activity transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1447 12991 Ensembl ENSG00000135222 ENSG00000283030 ENSMUSG00000063157 UniProt P05814 P10598 RefSeq (mRNA) NM_001302770 NM_001891 NM_001385731 NM_001286020 NM_001286021 NM_001286022 NM_001286023 NM_001286024 NM_009972 RefSeq (protein) NP_001289699 NP_001882 NP_001272949 NP_001272950 NP_001272951 NP_001272952 NP_001272953 NP_034102 Location (UCSC) Chr 4: 69.96 – 69.97 Mb Chr 5: 87.84 – 87.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Beta-casein is a protein that in humans is encoded by the CSN2 gene. It is in the class of phosphoproteins and generally occurs in mammalian milk.

External links

• Human CSN2 genome location and CSN2 gene details page in the UCSC Genome Browser.

Further reading

• Letwin K, Mizzen L, Motro B, et al. (1992). "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells". EMBO J. 11 (10): 3521–31. doi:10.1002/j.1460-2075.1992.tb05435.x. PMC 556810. PMID 1382974.
• Lönnerdal B, Bergström S, Andersson Y, et al. (1990). "Cloning and sequencing of a cDNA encoding human milk beta-casein". FEBS Lett. 269 (1): 153–6. doi:10.1016/0014-5793(90)81142-B. PMID 2387396. S2CID 84999340.
• Menon RS, Ham RG (1989). "Human beta-casein: partial cDNA sequence and apparent polymorphism". Nucleic Acids Res. 17 (7): 2869. doi:10.1093/nar/17.7.2869. PMC 317677. PMID 2717418.
• Greenberg R, Groves ML, Dower HJ (1984). "Human beta-casein. Amino acid sequence and identification of phosphorylation sites". J. Biol. Chem. 259 (8): 5132–8. doi:10.1016/S0021-9258(17)42966-8. PMID 6715339.
• Chen CS, Bejcek BE, Kersey JH (1995). "A mapping study of 13 genes on human chromosome bands 4q11→q25". Cytogenet. Cell Genet. 69 (3–4): 260–5. doi:10.1159/000133976. PMID 7698025.
• Hansson L, Edlund A, Johansson T, et al. (1994). "Structure of the human beta-casein encoding gene". Gene. 139 (2): 193–9. doi:10.1016/0378-1119(94)90754-4. PMID 8112603.
• McConkey EH, Menon R, Williams G, et al. (1996). "Assignment of the gene for beta-casein (CSN2) to 4q13 → q21 in humans and 3p13 → p12 in chimpanzees". Cytogenet. Cell Genet. 72 (1): 60–2. doi:10.1159/000134163. PMID 8565637.
• Wilmouth RC, Clifton IJ, Robinson CV, et al. (1997). "Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase". Nat. Struct. Biol. 4 (6): 456–62. doi:10.1038/nsb0697-456. PMID 9187653. S2CID 46268643.
• Winklehner-Jennewein P, Geymayer S, Lechner J, et al. (1998). "A distal enhancer region in the human beta-casein gene mediates the response to prolactin and glucocorticoid hormones". Gene. 217 (1–2): 127–39. doi:10.1016/S0378-1119(98)00380-1. PMID 9795185.
• Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
• Sood SM, Slatter CW (2003). "Suspension of the calcium-sensitive human beta-caseins by human kappa-casein". J. Dairy Sci. 85 (6): 1353–6. doi:10.3168/jds.S0022-0302(02)74200-8. PMID 12146463.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ohashi A, Murata E, Yamamoto K, et al. (2003). "New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors". Biochem. Biophys. Res. Commun. 306 (1): 98–103. doi:10.1016/S0006-291X(03)00917-3. PMID 12788072.
• Reimer T, Weiwad M, Schierhorn A, et al. (2003). "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14". J. Mol. Biol. 330 (5): 955–66. doi:10.1016/S0022-2836(03)00713-7. PMID 12860119.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miller SL, DeMaria JE, Freier DO, et al. (2005). "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor". Mol. Endocrinol. 19 (4): 939–49. doi:10.1210/me.2004-0443. PMID 15618286.
• Sood SM, Lekic T, Jhawar H, et al. (2007). "Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein". Protein J. 25 (5): 352–60. doi:10.1007/s10930-006-9022-7. PMID 16947075. S2CID 84941322.
• Buser AC, Gass-Handel EK, Wyszomierski SL, et al. (2007). "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells". Mol. Endocrinol. 21 (1): 106–25. doi:10.1210/me.2006-0297. PMID 16973758.