CIAO1

CIAO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FM0
Identifiers
Aliases	CIAO1, CIA1, WDR39, cytosolic iron-sulfur assembly component 1
External IDs	OMIM: 604333 MGI: 1346998 HomoloGene: 55850 GeneCards: CIAO1
Gene location (Human) Chr. Chromosome 2 (human) Band 2q11.2 Start 96,266,159 bp End 96,274,173 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 F1|2 61.86 cM Start 127,082,858 bp End 127,089,736 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence cerebellar hemisphere body of pancreas putamen nucleus accumbens monocyte external globus pallidus caudate nucleus Brodmann area 9 right lobe of liver Top expressed in right ventricle interventricular septum medial ganglionic eminence kidney lip adrenal gland seminal vesicula facial motor nucleus proximal tubule morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component CIA complex MMXD complex cytoplasm Biological process regulation of transcription by RNA polymerase II iron-sulfur cluster assembly positive regulation of cell population proliferation chromosome segregation protein maturation by iron-sulfur cluster transfer Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9391 26371 Ensembl ENSG00000144021 ENSMUSG00000003662 UniProt O76071 Q99KN2 RefSeq (mRNA) NM_004804 NM_025296 RefSeq (protein) NP_004795 NP_079572 Location (UCSC) Chr 2: 96.27 – 96.27 Mb Chr 2: 127.08 – 127.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Probable cytosolic iron-sulfur protein assembly protein CIAO1 is a protein that in humans is encoded by the CIAO1 gene. CIAO1 forms a complex with FAM96B, MMS19, the co-chaperone HSC20 and the scaffold protein ISCU in order to assist iron-sulfur cluster incorporation into cytoplasmic and nuclear iron-sulfur proteins.

External links

• Human CIAO1 genome location and CIAO1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (November 2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nature Cell Biology. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl:10397/34293. PMID 17041588. S2CID 22180568.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.