Protein-coding gene in the species Homo sapiens
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene .[5]
Interactions CENTG1 has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000135439 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025422 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: CENTG1 centaurin, gamma 1" .^ a b Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N" . Cell . 103 (6): 919–30. doi :10.1016/S0092-8674(00)00195-1 PMID 11136977 . S2CID 16610638 . ^ Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci . 6 (11): 1153–61. doi :10.1038/nn1134 . PMID 14528310 . S2CID 807407 .
External links Further reading
Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 3 (1): 17–24. doi :10.1093/dnares/3.1.17 PMID 8724849 . Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers" . Genomics . 42 (2): 295–301. doi :10.1006/geno.1997.4727 . PMID 9192850 . Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N" . Cell . 103 (6): 919–30. doi :10.1016/S0092-8674(00)00195-1 PMID 11136977 . S2CID 16610638 . Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH (2002). "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE". Nature . 415 (6871): 541–4. doi :10.1038/415541a . PMID 11823862 . S2CID 4371421 . Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA (2003). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton" . J. Biol. Chem . 277 (50): 48965–75. doi :10.1074/jbc.M202969200 PMID 12388557 . Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins" . Mol. Cell. Biol . 23 (7): 2476–88. doi :10.1128/MCB.23.7.2476-2488.2003 . PMC 150724 PMID 12640130 . Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci . 6 (11): 1153–61. doi :10.1038/nn1134 . PMID 14528310 . S2CID 807407 . Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K (2004). "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion" . J. Biol. Chem . 279 (16): 16441–51. doi :10.1074/jbc.M312175200 PMID 14761976 . Ahn JY, Hu Y, Kroll TG, Allard P, Ye K (2004). "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt" . Proc. Natl. Acad. Sci. U.S.A . 101 (18): 6993–8. Bibcode :2004PNAS..101.6993A . doi :10.1073/pnas.0400921101 PMC 406454 PMID 15118108 . Nie Z, Fei J, Premont RT, Randazzo PA (2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3" . J. Cell Sci . 118 (Pt 15): 3555–66. doi :10.1242/jcs.02486 PMID 16079295 . Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas". Neuropathol. Appl. Neurobiol . 31 (5): 486–90. doi :10.1111/j.1365-2990.2005.00660.x . PMID 16150119 . S2CID 21766234 . Hu Y, Liu Z, Ye K (2006). "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings" . Proc. Natl. Acad. Sci. U.S.A . 102 (46): 16853–8. doi :10.1073/pnas.0507365102 PMC 1283830 PMID 16263930 . Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival" . Cell Death Differ . 14 (2): 368–77. doi :10.1038/sj.cdd.4402011 PMID 16841086 . Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA (2007). "The centaurin gamma-1 GTPase-like domain functions as an NTPase" . Biochem. J . 401 (3): 679–88. doi :10.1042/BJ20060555 . PMC 1770848 PMID 17037982 . Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A" . J. Virol . 81 (5): 2340–8. doi :10.1128/JVI.01310-06 . PMC 1865929 PMID 17151107 . Liu X, Hu Y, Hao C, Rempel SA, Ye K (2007). "PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion". Oncogene . 26 (34): 4918–27. doi :10.1038/sj.onc.1210290 . PMID 17297440 . S2CID 1156814 . Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2" . Traffic . 8 (6): 661–72. doi :10.1111/j.1600-0854.2007.00561.x PMID 17461797 . S2CID 28218061 .
