CEACAM16
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| carcinoembryonic antigen-related cell adhesion molecule 16 | |
|---|---|
| Identifiers | |
| Symbol | CEACAM16 |
| NCBI gene | 388551 |
| HGNC | 31948 |
| RefSeq | XM_371177 |
| Other data | |
| Locus | Chr. 19 q13.31 |
CEACAM16 is a gene which encodes carcinoembryonic antigen. It is the only carcinoembryotic antigen found in the platypus. [1] The protein is expressed in mammalian outer hair cells, and mutations in this gene are associated with autosomal dominant nonsyndromic deafness.[2][3]
References
- ^ Kammerer R, Rüttiger L, Riesenberg R, Schäuble C, Krupar R, Kamp A, et al. (June 2012). "Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies". The Journal of Biological Chemistry. 287 (26): 21584–21598. doi:10.1074/jbc.M111.320481. PMC 3381124. PMID 22544735.
- ^ Zheng J, Miller KK, Yang T, Hildebrand MS, Shearer AE, DeLuca AP, et al. (March 2011). "Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)". Proceedings of the National Academy of Sciences of the United States of America. 108 (10): 4218–4223. Bibcode:2011PNAS..108.4218Z. doi:10.1073/pnas.1005842108. PMC 3054008. PMID 21368133.
- ^ Hofrichter MA, Nanda I, Gräf J, Schröder J, Shehata-Dieler W, Vona B, Haaf T (October 2015). "A Novel de novo Mutation in CEACAM16 Associated with Postlingual Hearing Impairment". Molecular Syndromology. 6 (4): 156–163. doi:10.1159/000439576. PMC 4662267. PMID 26648831.
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