Blood–brain barrier disruption

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Blood–brain barrier disruption is the surgical process whereby drugs are used to create openings between cells in the blood–brain barrier.[1]

Purpose

The blood–brain barrier (BBB) is protected by a network of blood vessels and tissue that shields it from harmful substances. This protection also stops anti-cancer drugs from getting to the brain. To treat brain tumours and other brain related diseases,[2][3] blood–brain barrier disruption is needed for the anti-cancer drugs to be infused into an artery that goes to the brain.[1]

Effects

Studies have shown that blood–brain barrier disruption can cause diseases in the central nervous system.[4][5]

References

  1. ^ a b "Definition of blood–brain barrier disruption". www.cancer.gov. 2011-02-02. Retrieved 2023-02-09.
  2. ^ Tomkins, O.; Shelef, I.; Kaizerman, I.; Eliushin, A.; Afawi, Z.; Misk, A.; Gidon, M.; Cohen, A.; Zumsteg, D.; Friedman, A. (2008-07-01). "Blood–brain barrier disruption in post-traumatic epilepsy". Journal of Neurology, Neurosurgery & Psychiatry. 79 (7): 774–777. doi:10.1136/jnnp.2007.126425. ISSN 0022-3050. PMID 17991703. S2CID 29504371.
  3. ^ InSightec (2023-01-18). "A Pivotal Study to Evaluate the Safety and Effectiveness of Exablate Model 4000 Using Microbubble Resonators to Temporarily Mediate Blood–brain barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors". {{cite journal}}: Cite journal requires |journal= (help)
  4. ^ Segura-Collar, Berta; Mata-Martínez, Pablo; Hernández-Laín, Aurelio; Sánchez-Gómez, Pilar; Gargini, Ricardo (June 2022). "Blood–brain barrier Disruption: A Common Driver of Central Nervous System Diseases". The Neuroscientist. 28 (3): 222–237. doi:10.1177/1073858420985838. hdl:20.500.12105/11670. ISSN 1089-4098. PMID 33446074. S2CID 231611519.
  5. ^ Okada, Takeshi; Suzuki, Hidenori; Travis, Zachary D.; Zhang, John H. (2020). "The Stroke-Induced Blood–brain barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target". Current Neuropharmacology. 18 (12): 1187–1212. doi:10.2174/1570159X18666200528143301. PMC 7770643. PMID 32484111.
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