BTBD2

BTBD2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3NO8
Identifiers
Aliases	BTBD2, BTB domain containing 2
External IDs	OMIM: 608531 MGI: 1933831 HomoloGene: 32365 GeneCards: BTBD2
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 1,985,438 bp End 2,034,881 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 80,478,451 bp End 80,492,905 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right uterine tube amygdala ganglionic eminence prefrontal cortex right lobe of thyroid gland Brodmann area 9 nucleus accumbens canal of the cervix left uterine tube Top expressed in interventricular septum superior frontal gyrus internal carotid artery external carotid artery saccule neural tube cerebellar cortex lip secondary oocyte otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component cytoplasm SCF ubiquitin ligase complex cytosol P-body Biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteolysis neurogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55643 208198 Ensembl ENSG00000133243 ENSMUSG00000003344 UniProt Q9BX70 n/a RefSeq (mRNA) NM_017797 NM_145361 NM_001379084 RefSeq (protein) NP_060267 n/a Location (UCSC) Chr 19: 1.99 – 2.03 Mb Chr 10: 80.48 – 80.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.

Function

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.

Interactions

BTBD2 has been shown to interact with TOP1.

External links

• Human BTBD2 genome location and BTBD2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9BX70 (BTB/POZ domain-containing protein 2) at the PDBe-KB.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2003). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
• Yamada A, Kawano K, Koga M, Takamori S, Nakagawa M, Itoh K (Jun 2003). "Gene and peptide analyses of newly defined lung cancer antigens recognized by HLA-A2402-restricted tumor-specific cytotoxic T lymphocytes". Cancer Research. 63 (11): 2829–35. PMID 12782588.
• Xu L, Yang L, Moitra PK, Hashimoto K, Rallabhandi P, Kaul S, Meroni G, Jensen JP, Weissman AM, D'Arpa P (Aug 2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta". Experimental Cell Research. 288 (1): 84–93. doi:10.1016/S0014-4827(03)00187-3. PMID 12878161.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.