Protein-coding gene in the species Homo sapiens
TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene .[5] [6] [7]
Function Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM][7]
Interactions BTAF1 has been shown to interact with TATA binding protein .[6] [8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000095564 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040565 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT (Dec 1997). "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila" . Proc Natl Acad Sci U S A . 94 (22): 11827–32. Bibcode :1997PNAS...9411827V . doi :10.1073/pnas.94.22.11827 PMC 23617 PMID 9342322 . ^ a b Chicca JJ, Auble DT, Pugh BF (Mar 1998). "Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1" . Mol Cell Biol . 18 (3): 1701–10. doi :10.1128/MCB.18.3.1701 . PMC 108885 PMID 9488487 . ^ a b "Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)" .^ Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme" . Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode :1997PNAS...94.5605S . doi :10.1073/pnas.94.11.5605 PMC 20825 PMID 9159119 .
External links Further reading
Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat" . EMBO J . 14 (2): 321–8. doi :10.1002/j.1460-2075.1995.tb07006.x . PMC 398086 PMID 7835343 . Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro" . J. Biol. Chem . 270 (5): 2274–83. doi :10.1074/jbc.270.5.2274 PMID 7836461 . Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function" . J. Virol . 68 (11): 7188–99. doi :10.1128/JVI.68.11.7188-7199.1994 . PMC 237158 PMID 7933101 . Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang CM, Roeder RG, Brady JN (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature . 367 (6460): 295–9. Bibcode :1994Natur.367..295K . doi :10.1038/367295a0 . PMID 8121496 . S2CID 4362048 . Wang Z, Morris GF, Rice AP, Xiong W, Morris CB (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro" . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol . 12 (2): 128–38. doi :10.1097/00042560-199606010-00005 PMID 8680883 . Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly" . J. Virol . 70 (8): 5025–34. doi :10.1128/JVI.70.8.5025-5034.1996 . PMC 190456 PMID 8764009 . Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex" . J. Virol . 70 (8): 5503–10. doi :10.1128/JVI.70.8.5503-5510.1996 . PMC 190508 PMID 8764062 . Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science . 274 (5287): 605–10. Bibcode :1996Sci...274..605Z . doi :10.1126/science.274.5287.605 . PMID 8849451 . S2CID 13266489 . García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes" . J. Biol. Chem . 272 (11): 6951–8. doi :10.1074/jbc.272.11.6951 PMID 9054383 . Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme" . Proc. Natl. Acad. Sci. U.S.A . 94 (11): 5605–10. Bibcode :1997PNAS...94.5605S . doi :10.1073/pnas.94.11.5605 PMC 20825 PMID 9159119 . Van Der Knaap JA, Van Den Boom V, Kuipers J, Van Eijk MJ, Van Der Vliet PC, Timmers HT (2000). "The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization" . Biochem. J . 345 (3): 521–7. doi :10.1042/0264-6021:3450521 . PMC 1220786 PMID 10642510 . Wadhwa R, Yaguchi T, Hasan MK, Taira K, Kaul SC (2003). "Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation". Biochem. Biophys. Res. Commun . 302 (4): 735–42. doi :10.1016/S0006-291X(03)00226-2 . PMID 12646231 . Pereira LA, Klejman MP, Ruhlmann C, Kavelaars F, Oulad-Abdelghani M, Timmers HT, Schultz P (2004). "Molecular architecture of the basal transcription factor B-TFIID" . J. Biol. Chem . 279 (21): 21802–7. doi :10.1074/jbc.M313519200 PMID 14988402 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Klejman MP, Pereira LA, van Zeeburg HJ, Gilfillan S, Meisterernst M, Timmers HT (2004). "NC2α Interacts with BTAF1 and Stimulates Its ATP-Dependent Association with TATA-Binding Protein" . Mol. Cell. Biol . 24 (22): 10072–82. doi :10.1128/MCB.24.22.10072-10082.2004 . PMC 525489 PMID 15509807 . Grob P, Cruse MJ, Inouye C, Peris M, Penczek PA, Tjian R, Nogales E (2006). "Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues" . Structure . 14 (3): 511–20. doi :10.1016/j.str.2005.11.020 PMID 16531235 .
