BMP2K

BMP2K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4W9W, 4W9X, 5I3R, 5I3O, 5IKW
Identifiers
Aliases	BMP2K, BIKE, HRIHFB2017, BMP2 inducible kinase
External IDs	OMIM: 617648 MGI: 2155456 HomoloGene: 34134 GeneCards: BMP2K
Gene location (Human) Chr. Chromosome 4 (human) Band 4q21.21 Start 78,776,342 bp End 78,916,365 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E3 Start 97,145,548 bp End 97,239,726 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone sural nerve rectum monocyte amniotic fluid lymph node appendix Achilles tendon stromal cell of endometrium Top expressed in secondary oocyte blood spleen hair follicle cumulus cell vas deferens body of femur substantia nigra subcutaneous adipose tissue pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity ATP binding protein serine/threonine kinase activity phosphatase regulator activity AP-2 adaptor complex binding Cellular component nuclear speck nucleus cytoplasm Biological process regulation of catalytic activity phosphorylation regulation of bone mineralization protein phosphorylation positive regulation of Notch signaling pathway regulation of clathrin-dependent endocytosis regulation of endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55589 140780 Ensembl ENSG00000138756 ENSMUSG00000034663 UniProt Q9NSY1 Q91Z96 RefSeq (mRNA) NM_017593 NM_198892 NM_080708 RefSeq (protein) NP_060063 NP_942595 NP_542439 Location (UCSC) Chr 4: 78.78 – 78.92 Mb Chr 5: 97.15 – 97.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.

Function

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.

External links

• Human BMP2K genome location and BMP2K gene details page in the UCSC Genome Browser.

Further reading

• Hoffmann A, Gross G (2002). "BMP signaling pathways in cartilage and bone formation". Critical Reviews in Eukaryotic Gene Expression. 11 (1–3): 23–45. PMID 11693963.
• Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. S2CID 20001769.
• Kearns AE, Donohue MM, Sanyal B, Demay MB (Nov 2001). "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro". The Journal of Biological Chemistry. 276 (45): 42213–8. doi:10.1074/jbc.M106163200. PMID 11500515.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Arikawa T, Omura K, Morita I (Sep 2004). "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells". Journal of Cellular Physiology. 200 (3): 400–6. doi:10.1002/jcp.20031. PMID 15254968. S2CID 28129401.
• Medici M, van Meurs JB, Rivadeneira F, Zhao H, Arp PP, Hofman A, Pols HA, Uitterlinden AG (Jun 2006). "BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study". Journal of Bone and Mineral Research. 21 (6): 845–54. doi:10.1359/jbmr.060306. PMID 16753015. S2CID 25680897.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.