Asthma Life Impact Scale

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Asthma Life Impact Scale
Purposemeasures asthma effect on quality of life

The Asthma Life Impact Scale (ALIS) measure is a disease-specific patient reported outcome questionnaire which assesses the impact that asthma has on a patient’s quality of life.[1]

The questionnaire has 22 items,[1] which goes beyond earlier focus on the symptoms, functioning and environmental triggers of asthma and includes emotional issues.[2]


In 2019 it was estimated that some 262 million individuals worldwide suffered from asthma[3]

The ALIS was developed simultaneously in the UK and in the US via interviews and focus groups.[4]

It was developed and published in 2010 by Galen Research, and was funded by Novartis AG.[1]

It was the first asthma specific quality of life measure that was developed using Item Response Theory.[5]

Items that were featured on the ALIS include: “asthma restricts my social activities”; “asthma affect my close relationships”, “my illness controls me” and “my asthma affects my interest in sex”.[6]

International use

Currently, the ALIS has been translated into 16 different languages,[7] including Russian and Italian.[5]


  1. 1.0 1.1 1.2 Meads, David M.; McKenna, Stephen P.; Doward, Lynda C.; Pokrzywinski, Robin; Revicki, Dennis; Hunter, Cameron; Glendenning, G. Alastair (May 2010). "Development and validation of the Asthma Life Impact Scale (ALIS)". Respiratory Medicine. 104 (5): 633–643. doi:10.1016/j.rmed.2009.11.023. PMID 20053543.
  2. Shen, Joannie; Johnston, Michael; Hays, Ron D. (2011). "Asthma Outcome Measures" (PDF). Expert Review of Pharmacoeconomics & Outcomes Research. 11 (4): 447–453. doi:10.1586/erp.11.48. PMID 21831026. S2CID 207222294. Archived from the original (PDF) on 17 October 2013. Retrieved 14 October 2013.
  3. "Asthma". Archived from the original on 2020-03-05. Retrieved 2024-05-14.
  4. Crawford, S.R.; McKenna, S.; Twiss, J.; Tammaru, M.; Oprandi, N.C. (November 2011). "PRS53 Further Developments of the Asthma Life Impact Scale (ALIS)". Value in Health. 14 (7): A497. doi:10.1016/j.jval.2011.08.1440. Archived from the original on 15 May 2024. Retrieved 14 October 2013.
  5. 5.0 5.1 Twiss, J.; McKenna, S.P.; Crawford, S.R.; Tammaru, M.; Oprandi, N.C. (2011). "Adapting the Asthma Life Impact Scale (ALIS) for use in Southern European (Italian) and Eastern European (Russian) cultures". Journal of Medical Economics. 14 (6): 729–738. doi:10.3111/13696998.2011.615356. PMID 21899487. S2CID 35393631.
  6. Piper, Lucy (2010-05-11). "Asthma Life Impact Scale is 'reliable and valid'". Medwire News. Archived from the original on 2013-10-15. Retrieved 14 October 2013.
  7. Crawford, SR. "Further Developments of the Asthma Life Impact Scale (ALIS)" (PDF). Galen Research. Archived (PDF) from the original on 24 September 2015. Retrieved 14 October 2013.