Aspoxicillin

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Aspoxicillin
Clinical data
Trade namesDoyle
Other namesTA-058
Identifiers
  • (2S,5R,6R)-6-[[(2R)-2-[[(2R)-2-Amino-4-(methylamino)-4-oxobutanoyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS Number
PubChem CID
DrugBank
UNII
Chemical and physical data
FormulaC21H27N5O7S
Molar mass493.54 g·mol−1

Aspoxicillin (trade name Doyle[1]) is an antibiotic drug of the beta-lactam class.[2] It is an injectable form of penicillin that is highly active against Gram-positive and Gram-negative bacteria, including Bacillus fragilis,[3] which is resistant to other beta-lactam antibiotics.[4] It is approved for use in Japan.[1]

References

  1. ^ a b "Aspoxicillin". IUPHAR/BPS Guide to Pharmacology.
  2. ^ Matsumoto, K. (1987). "Review: New antimicrobial agent series XXII: Aspoxicillin". The Japanese Journal of Antibiotics. 40 (7): 1221–1242. PMID 3316732.
  3. ^ "Aspoxicillin". Inxight Drugs. National Center for Advancing Translational Sciences.
  4. ^ Edwards, R. (1997). "Resistance to -Lactam Antibiotics in Bacteroides SPP". Journal of Medical Microbiology. 46 (12): 979–986. doi:10.1099/00222615-46-12-979. PMID 9402919.
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