Aminoadipate-semialdehyde dehydrogenase

AASDH
Identifiers
Aliases	AASDH, ACSF4, LYS2, NRPS1098, NRPS998, aminoadipate-semialdehyde dehydrogenase
External IDs	OMIM: 614365 MGI: 2442517 HomoloGene: 71711 GeneCards: AASDH
EC number	1.2.1.31
Gene location (Human) Chr. Chromosome 4 (human) Band 4q12 Start 56,338,287 bp End 56,387,508 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 C3.3 Start 77,021,506 bp End 77,053,361 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell nipple corpus epididymis caput epididymis renal medulla oocyte tibialis anterior muscle sperm pylorus deltoid muscle Top expressed in Paneth cell otolith organ utricle conjunctival fornix fossa ciliary body iris spermatocyte condyle hand More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 132949 231326 Ensembl ENSG00000157426 ENSMUSG00000055923 UniProt Q4L235 Q80WC9 RefSeq (mRNA) NM_001286668 NM_001286669 NM_001286670 NM_001286671 NM_001286672 NM_181806 NM_001323890 NM_001323892 NM_001323893 NM_001323899 NM_173765 NM_001377004 RefSeq (protein) NP_001273597 NP_001273598 NP_001273599 NP_001273600 NP_001273601 NP_001310819 NP_001310821 NP_001310822 NP_001310828 NP_861522 NP_776126 NP_001363933 Location (UCSC) Chr 4: 56.34 – 56.39 Mb Chr 5: 77.02 – 77.05 Mb PubMed search
Wikidata
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Aminoadipate-semialdehyde dehydrogenase is a protein that in humans is encoded by the AASDH gene.

Function

This gene encodes a member of the non-ribosome peptide synthetase (NRPS) enzyme family. The encoded protein contains an AMP-binding domain, PP-binding (phosphopantetheine, or pantetheine 4'phosphate-binding) domain and the Pyrrolo-quinoline quinon (PQQ) binding domain. The protein is expressed in several adult tissues.

Further reading

• Wang L, Jil C, Xu Y, Xu J, Dai J, Wu Q, Wu M, Zou X, Sun L, Gu S, Xie Y, Mao Y (2005). "Cloning and characterization of a novel human homolog* of mouse U26, a putative PQQ-dependent AAS dehydrogenase". Mol. Biol. Rep. 32 (1): 47–53. doi:10.1007/s11033-003-2716-4. PMID 15865210. S2CID 26141158.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.