Protein-coding gene in the species Homo sapiens
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene .[5]
Function This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex /cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome -mediated degradation through ubiquitination . The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators .[5]
Interactions ANAPC7 has been shown to interact with ANAPC1 ,[6] [7] ANAPC4 ,[6] CDC27 [6] [8] CDC20 .[6] [9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000196510 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029466 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7" .^ a b c d Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68. Bibcode :2003CBio...13.1459V . doi :10.1016/S0960-9822(03)00581-5 PMID 12956947 . S2CID 5942532 . ^ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase" . J. Cell Biol . 151 (4): 749–62. doi :10.1083/jcb.151.4.749 . PMC 2169443 PMID 11076961 . ^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A . 97 (16): 8973–8. Bibcode :2000PNAS...97.8973G . doi :10.1073/pnas.97.16.8973 PMC 16806 PMID 10922056 . ^ Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction" . Nat. Cell Biol . 10 (12): 1411–20. doi :10.1038/ncb1799 . PMC 2635557 PMID 18997788 .
External links Further reading
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Yu H, Peters JM, King RW, et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science . 279 (5354): 1219–22. Bibcode :1998Sci...279.1219Y . doi :10.1126/science.279.5354.1219 . PMID 9469815 . Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex" . J. Biol. Chem . 274 (20): 14500–7. doi :10.1074/jbc.274.20.14500 PMID 10318877 . Chan GK, Jablonski SA, Sudakin V, et al. (1999). "Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC" . J. Cell Biol . 146 (5): 941–54. doi :10.1083/jcb.146.5.941 . PMC 2169490 PMID 10477750 . Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons" . Proc. Natl. Acad. Sci. U.S.A . 96 (20): 11317–22. Bibcode :1999PNAS...9611317G . doi :10.1073/pnas.96.20.11317 PMC 18031 PMID 10500174 . Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A . 97 (16): 8973–8. Bibcode :2000PNAS...97.8973G . doi :10.1073/pnas.97.16.8973 PMC 16806 PMID 10922056 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68. Bibcode :2003CBio...13.1459V . doi :10.1016/S0960-9822(03)00581-5 PMID 12956947 . S2CID 5942532 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Park KH, Choi SE, Eom M, Kang Y (2006). "Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships" . Breast Cancer Res . 7 (2): R238–47. doi :10.1186/bcr978 PMC 1064132 PMID 15743504 . Turnell AS, Stewart GS, Grand RJ, et al. (2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature . 438 (7068): 690–5. Bibcode :2005Natur.438..690T . doi :10.1038/nature04151 . PMID 16319895 . S2CID 4432156 .
