8-Hydroxygeraniol dehydrogenase
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| 8-Hydroxygeraniol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.324 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
8-hydroxygeraniol dehydrogenase (EC 1.1.1.324, 8-hydroxygeraniol oxidoreductase, CYP76B10, G10H, CrG10H, SmG10H, acyclic monoterpene primary alcohol:NADP+ oxidoreductase) is an enzyme with systematic name (6E)-8-hydroxygeraniol:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- (6E)-8-hydroxygeraniol + 2 NADP+ (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction)
- (1a) (6E)-8-hydroxygeraniol + NADP+ (6E)-8-hydroxygeranial + NADPH + H+
- (1b) (6E)-8-hydroxygeraniol + NADP+ (6E)-8-oxogeraniol + NADPH + H+
- (1c) (6E)-8-hydroxygeranial + NADP+ (6E)-8-oxogeranial + NADPH + H+
- (1d) (6E)-8-oxogeraniol + NADP+ (6E)-8-oxogeranial + NADPH + H+
This enzyme contains Zn2+. It catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol.
References
- ^ Ikeda H, Esaki N, Nakai S, Hashimoto K, Uesato S, Soda K, Fujita T (February 1991). "Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols". Journal of Biochemistry. 109 (2): 341–7. PMID 1864846.
- ^ Hallahan DL, West JM, Wallsgrove RM, Smiley DW, Dawson GW, Pickett JA, Hamilton JG (April 1995). "Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa)". Archives of Biochemistry and Biophysics. 318 (1): 105–12. doi:10.1006/abbi.1995.1210. PMID 7726550.
External links
- 8-hydroxygeraniol+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
