2-oxoaldehyde dehydrogenase (NAD+)

2-oxoaldehyde dehydrogenase (NAD)
Identifiers
EC no.	1.2.1.23
CAS no.	37250-91-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (EC 1.2.1.23) is an enzyme that catalyzes the chemical reaction

a 2-oxoaldehyde + NAD⁺ + H₂O $\rightleftharpoons$ a 2-oxo acid + NADH + H⁺

The 3 substrates of this enzyme are 2-oxoaldehyde, NAD⁺, and H₂O, whereas its 3 products are 2-oxo acid, NADH, and H⁺.

This enzyme participates in pyruvate metabolism.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include:

• alpha-ketoaldehyde dehydrogenase
• methylglyoxal dehydrogenase
• NAD+-linked alpha-ketoaldehyde dehydrogenase
• 2-ketoaldehyde dehydrogenase
• NAD+-dependent alpha-ketoaldehyde dehydrogenase
• 2-oxoaldehyde dehydrogenase (NAD+)

See also

• 2-oxoaldehyde dehydrogenase (NADP+)

References

• Monder C (1967). "Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 242 (20): 4603–9. PMID 4383524.
• Ray M, Ray S (1982). "On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase". J. Biol. Chem. 257 (18): 10571–4. PMID 7107626.
• Ray S, Ray M (1982). "Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 257 (18): 10566–70. PMID 7107625.