2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
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| OHCU decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | OHCU_decarbox | ||||||||
| Pfam | PF09349 | ||||||||
| InterPro | IPR018020 | ||||||||
| |||||||||
In molecular biology 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) EC 4.1.1.n1 is an enzyme involved in purine catabolism. It catalyses the decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) into S(+)-allantoin.[1][2] It is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase and step two is catalysed by hydroxyisourate hydrolase.[3][4]
References
- ^ Ramazzina I, Folli C, Secchi A, Berni R, Percudani R (March 2006). "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes". Nat. Chem. Biol. 2 (3): 144–8. doi:10.1038/nchembio768. PMID 16462750. S2CID 13441301.
- ^ Cendron L, Berni R, Folli C, Ramazzina I, Percudani R, Zanotti G (2007). "The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation". J Biol Chem. 282 (25): 18182–9. doi:10.1074/jbc.M701297200. hdl:11577/1777398. PMID 17428786.
- ^ Kim K, Park J, Rhee S (2007). "Structural and functional basis for (S)-allantoin formation in the ureide pathway". J Biol Chem. 282 (32): 23457–64. doi:10.1074/jbc.M703211200. PMID 17567580.
- ^ Todd CD, Tipton PA, Blevins DG, Piedras P, Pineda M, Polacco JC (2006). "Update on ureide degradation in legumes". J Exp Bot. 57 (1): 5–12. doi:10.1093/jxb/erj013. PMID 16317038.