Tetraspanin 9

TSPAN9
Identifiers
Aliases	TSPAN9, NET-5, NET5, PP1057, tetraspanin 9
External IDs	OMIM: 613137 MGI: 1924558 HomoloGene: 4860 GeneCards: TSPAN9
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.33-p13.32 Start 3,077,355 bp End 3,286,564 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F3 Start 127,938,359 bp End 128,120,557 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere left ventricle right lung right lobe of liver stromal cell of endometrium vena cava gallbladder right ventricle kidney upper lobe of left lung Top expressed in yolk sac cerebellar cortex internal carotid artery lip right lung iris external carotid artery belly cord right lung lobe ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component integral component of membrane plasma membrane tetraspanin-enriched microdomain integral component of plasma membrane membrane focal adhesion Biological process cell surface receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10867 109246 Ensembl ENSG00000011105 ENSMUSG00000030352 UniProt O75954 Q8BJU2 RefSeq (mRNA) NM_001168320 NM_006675 NM_175414 NM_001356301 NM_001379133 NM_001379134 NM_001379135 NM_001379136 RefSeq (protein) NP_001161792 NP_006666 NP_780623 NP_001343230 NP_001366062 NP_001366063 NP_001366064 NP_001366065 Location (UCSC) Chr 12: 3.08 – 3.29 Mb Chr 6: 127.94 – 128.12 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Tetraspanin 9 is a protein that in humans is encoded by the TSPAN9 gene.

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009].

Further reading

• Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JM, Bicknell R, Senis YA, Ashman LK, Berditchevski F, Ouwehand WH, Watson SP, Tomlinson MG (2009). "Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains". Biochem. J. 417 (1): 391–400. doi:10.1042/BJ20081126. PMC 2652832. PMID 18795891.
• Kotha J, Zhang C, Longhurst CM, Lu Y, Jacobs J, Cheng Y, Jennings LK (2009). "Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia". Atherosclerosis. 203 (2): 377–86. doi:10.1016/j.atherosclerosis.2008.07.036. PMID 18799160.
• Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC (2009). "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease". Mol. Psychiatry. 14 (11): 1004–16. doi:10.1038/mp.2009.10. PMC 2860783. PMID 19204726.
• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
• Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
• Stiles KM, Kielian M (2016). "Role of TSPAN9 in Alphavirus Entry and Early Endosomes". J. Virol. 90 (9): 4289–97. doi:10.1128/JVI.00018-16. PMC 4836341. PMID 26865714.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.