Syncope (PECS)
Context
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Pathophysiology, history, and physical exam
Cardiac
Mortality >10% at 6 months.
- Arrhythmias: Most common cause of cardiac syncope.
- No prodrome.
- Sudden LOC and may report palpitations prior to the event.
- Occurs in any position.
- Family history of arrhythmia, inherited cardiac disorders, sudden unexplained cardiac death, drowning, unexplained seizures.
Syncope in the setting of exercise is due to cardiac arrhythmia until proven otherwise.
- Structural lesions:
- Valvular and cardiomyopathies: murmurs or signs of CHF require further workup – often need echocardiogram.
- Pulmonary emboli unlikely to present as an isolated syncope given that if there is enough clot burden to obstruct the blood flow, there should be other findings such as SOB, tachycardia, ECG changes.
- Ischemia: Infrequent cause (<3%) and often will have concomitant findings (such as massive STEMI on ECG or classic CP).
Orthostatic
Autonomic system fails to maintain blood pressure with increased heart rate. Often have positional component, such as onset when standing up from sitting position.
- Orthostatic vital signs neither sensitive nor specific and cannot be used in isolation to rule in or out this as cause of syncope.
- Medications: Antihypertensives, diuretics, antidepressants, beta-blockers, alpha-blockers.
- Postprandial hypotension: onset shortly after a meal.
- Intravascular volume loss: dehydration (vomiting, diarrhea, decreased po intake), hemorrhagic (GI, occult trauma, AAA, splenic rupture, retroperitoneal bleeds, etc).
!!!SO MAY NOT BE THAT BENIGN AFTER ALL –> thorough exam, including rectal for melena and bedside US for AAA, in appropriate settings and in elderly/high-risk patients
Reflex-mediated
Autonomic system acts inappropriately resulting in reflex bradycardia and vasodilation. Benign cause of syncope with excellent prognosis.
- Vasovagal: prodrome, induced by emotion or pain.
- Situational: cough, micturition, defecation.
- Carotid sinus hypersensitivity: older, male, stimulation of carotid sinus (necktie, shaving, etc).
Neurologic
Transient interruption of blood flow to the brain stem or cerebral cortex.
- Isolated syncope is rare (<1%).
- Routine use of CT head for syncope is not indicated.
- TIA and SAH patients have additional symptoms such as headache (SAH) and/or posterior circulation neurological findings (vertebrobasilar TIA).
- Subclavian steal syndrome – stenotic subclavian artery receives additional blood from the vertebral artery drawing it away from the brainstem. There often will be a difference in the blood pressure in each arm and additional posterior circulation deficits. Patient may report using the affected arm prior to the syncope.
Investigations
ECG
- Only mandatory test for all syncope patients.
- Ottawa group found that the patients were at risk for cardiac outcome within 30 days if any of the following were present: (see below related resources)
- Ottawa ECG Criteria[2]
- High degree blocks (2nd degree type II or 3rd degree AV)
- Bundle branch + 1st degree block
- RBB + left anterior or posterior block[3]
- Ischemic changes
- Non-sinus rhythm
- Left axis deviation
- ED cardiac monitor abnormalities
- Above ECG criteria likely to under-represent those with rare diagnosis, such as channelopathies, cardiomyopathies, and other inherited arrhythmogenic conditions. Therefore, ECGs (particularly those of younger patients) should be carefully examined for the following abnormalities:
Other investigations
- Investigations beyond ECG are required in cases where serious etiology is suspected or where it is not possible to determine the exact cause of syncope based solely on history and physical exam. These may include blood work, CXR, echocardiogram, telemetry, or Holter monitoring. The choice of the investigations is based on the presentation.[4]
Risk stratification tools
- San Francisco Syncope Rule Criteria[5]
- Congestive Heart Failure History
- Hematocrit < 30%
- ECG Abnormal?
- Shortness of Breath History
- Systolic BP < 90 mmHg at Triage
- Important: Pooled sensitivity was 86%. 1.4% of patients who are San Francisco Rule negative will have an adverse event at 7 days. Majority (60%) of missed diagnosis were arrhythmias. Also the rule did not exclude patients for whom the cause of the syncope was obvious, therefore making it unclear if this can be applied to undifferentiated syncope patients.[1]
- Canadian Syncope Risk Score (not prospectively validated yet)[6]
Important: Apply this score when there is a doubt as to potential etiology of syncope. The score predicts adverse events in the next 30 days (versus 7 days in San Francisco Rule). Patients with high score will require further evaluation.[5]
Quality of evidence
Approach to the syncope in ED: Based on expert opinion.
References
- ↑ 1.0 1.1 Group, Graham Walker and The NNT. "Syncope in the Emergency Department". TheNNT. Archived from the original on 26 January 2021. Retrieved 21 January 2021.
- ↑ Thiruganasambandamoorthy, V; Hess, EP; Turko, E; Tran, ML; Wells, GA; Stiell, IG (July 2012). "Defining abnormal electrocardiography in adult emergency department syncope patients: the Ottawa Electrocardiographic Criteria". CJEM. 14 (4): 248–58. PMID 22813399.
- ↑ Grados, OB (April 1975). "[The laboratory in programs for enteric infection control]". Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau. 78 (4): 318–22. PMID 123456.
- ↑ Ouyang, H; Quinn, J (August 2010). "Diagnosis and evaluation of syncope in the emergency department". Emergency medicine clinics of North America. 28 (3): 471–85. doi:10.1016/j.emc.2010.03.007. PMID 20709239.
- ↑ 5.0 5.1 Quinn, JV; Stiell, IG; McDermott, DA; Sellers, KL; Kohn, MA; Wells, GA (February 2004). "Derivation of the San Francisco Syncope Rule to predict patients with short-term serious outcomes". Annals of emergency medicine. 43 (2): 224–32. doi:10.1016/s0196-0644(03)00823-0. PMID 14747812.
- ↑ Thiruganasambandamoorthy, V; Kwong, K; Wells, GA; Sivilotti, MLA; Mukarram, M; Rowe, BH; Lang, E; Perry, JJ; Sheldon, R; Stiell, IG; Taljaard, M (6 September 2016). "Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope". CMAJ : Canadian Medical Association. 188 (12): E289–E298. doi:10.1503/cmaj.151469. PMID 27378464.
Related resources
Resource author (s)
- Dr. Ekaterina Alexeeva