Muskelin

MKLN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PQQ
Identifiers
Aliases	MKLN1, TWA2, muskelin 1
External IDs	OMIM: 605623 MGI: 1351638 HomoloGene: 8305 GeneCards: MKLN1
Gene location (Human) Chr. Chromosome 7 (human) Band 7q32.3 Start 131,110,096 bp End 131,496,632 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A3.3 Start 31,375,670 bp End 31,493,746 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon jejunal mucosa nipple lower lobe of lung corpus callosum secondary oocyte caput epididymis superficial temporal artery seminal vesicula urethra Top expressed in spermatocyte yolk sac spermatid duodenum neural tube lip proximal tubule superior frontal gyrus stomach left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function identical protein binding protein binding protein homodimerization activity Cellular component cytoplasm ruffle cytosol cell projection cell cortex ubiquitin ligase complex nucleoplasm nucleus cell junction synapse Biological process actin cytoskeleton reorganization cell-matrix adhesion signal transduction regulation of cell shape regulation of receptor internalization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4289 27418 Ensembl ENSG00000128585 ENSMUSG00000025609 UniProt Q9UL63 O89050 RefSeq (mRNA) NM_001145354 NM_013255 NM_001321316 NM_013791 RefSeq (protein) NP_001138826 NP_001308245 NP_037387 NP_038819 Location (UCSC) Chr 7: 131.11 – 131.5 Mb Chr 6: 31.38 – 31.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Muskelin is a protein that in humans is encoded by the MKLN1 gene.

Interactions

MKLN1 has been shown to interact with RANBP9.

Further reading

• Adams JC, Seed B, Lawler J (1998). "Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1". EMBO J. 17 (17): 4964–74. doi:10.1093/emboj/17.17.4964. PMC 1170825. PMID 9724633.
• Hasegawa H, Katoh H, Fujita H, et al. (2000). "Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin". Biochem. Biophys. Res. Commun. 276 (1): 350–4. doi:10.1006/bbrc.2000.3467. PMID 11006128.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Umeda M, Nishitani H, Nishimoto T (2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303: 47–54. doi:10.1016/S0378-1119(02)01153-8. PMID 12559565.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Prag S, Collett GD, Adams JC (2004). "Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association". Biochem. J. 381 (Pt 2): 547–59. doi:10.1042/BJ20040253. PMC 1133863. PMID 15084145.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Kobayashi N, Yang J, Ueda A, et al. (2007). "RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex". Gene. 396 (2): 236–47. doi:10.1016/j.gene.2007.02.032. PMID 17467196.