Protein-coding gene in the species Homo sapiens
Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene .[5] [6]
Interactions KLHL12 has been shown to interact with RIT1 [7] CUL3 .[7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000117153 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026455 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proceedings of the National Academy of Sciences of the United States of America . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . ^ "Entrez Gene: KLHL12 kelch-like 12 (Drosophila)" .^ a b Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (April 2008). "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase" . The Journal of Biological Chemistry . 283 (17): 11083–96. doi :10.1074/jbc.M708473200 PMC 2431063 PMID 18303015 .
Further reading
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Mai A, Jung SK, Yonehara S (October 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research . 300 (1): 72–83. doi :10.1016/j.yexcr.2004.06.023 . PMID 15383316 . Uchida K, Akita Y, Matsuo K, Fujiwara S, Nakagawa A, Kazaoka Y, et al. (September 2005). "Identification of specific autoantigens in Sjögren's syndrome by SEREX" . Immunology . 116 (1): 53–63. doi :10.1111/j.1365-2567.2005.02197.x . PMC 1802401 PMID 16108817 . Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT (April 2006). "The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation". Nature Cell Biology . 8 (4): 348–57. doi :10.1038/ncb1381 . PMID 16547521 . S2CID 7270083 . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 .
