Golgin subfamily A member 2

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GOLGA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGOLGA2, GM130, golgin A2
External IDsOMIM: 602580 MGI: 2139395 HomoloGene: 3300 GeneCards: GOLGA2
Orthologs
SpeciesHumanMouse
Entrez

2801

99412

Ensembl

ENSG00000167110

ENSMUSG00000002546

UniProt

Q08379

Q921M4

RefSeq (mRNA)

NM_004486
NM_001366244
NM_001366246

RefSeq (protein)

NP_004477
NP_001353173
NP_001353175

Location (UCSC)Chr 9: 128.26 – 128.28 MbChr 2: 32.18 – 32.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Golgin subfamily A member 2, also known as 130 kDa cis-Golgi matrix protein 1 (GM130) is a protein that in humans is encoded by the GOLGA2 gene.[5]

Function

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis.[6] The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.[7]

A patient with a neuromuscular disorder has been identified that is homozygous for a deletion mutation in this gene, and morpholino knockdown in zebrafish has shown similar phenotypes.[8]

Interactions

GOLGA2 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167110 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002546 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fritzler MJ, Hamel JC, Ochs RL, Chan EK (Jul 1993). "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex". The Journal of Experimental Medicine. 178 (1): 49–62. doi:10.1084/jem.178.1.49. PMC 2191081. PMID 8315394.
  6. ^ Mascanzoni F, Iannitti R, Colanzi A (January 2022). "Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle". Cells. 11 (3): 354. doi:10.3390/cells11030354. PMC 8834581. PMID 35159164.
  7. ^ "Entrez Gene: GOLGA2 golgi autoantigen, golgin subfamily a, 2".
  8. ^ Shamseldin HE, Bennett AH, Alfadhel M, Gupta V, Alkuraya FS (2016). "GOLGA2, encoding a master regulator of golgi apparatus, is mutated in a patient with a neuromuscular disorder". Human Genetics. 135 (2): 245–51. doi:10.1007/s00439-015-1632-8. PMC 4975006. PMID 26742501.
  9. ^ a b c d Pfeffer SR (Dec 2001). "Constructing a Golgi complex". The Journal of Cell Biology. 155 (6): 873–5. doi:10.1083/jcb.200109095. PMC 2150916. PMID 11739400.
  10. ^ a b Shorter J, Watson R, Giannakou ME, Clarke M, Warren G, Barr FA (Sep 1999). "GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system". The EMBO Journal. 18 (18): 4949–60. doi:10.1093/emboj/18.18.4949. PMC 1171566. PMID 10487747.
  11. ^ a b Barr FA, Preisinger C, Kopajtich R, Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal of Cell Biology. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.
  12. ^ Marra P, Maffucci T, Daniele T, Tullio GD, Ikehara Y, Chan EK, Luini A, Beznoussenko G, Mironov A, De Matteis MA (Dec 2001). "The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment". Nature Cell Biology. 3 (12): 1101–13. doi:10.1038/ncb1201-1101. PMID 11781572. S2CID 25743225.
  13. ^ Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and Biophysical Research Communications. 306 (1): 79–86. doi:10.1016/s0006-291x(03)00918-5. PMID 12788069.
  14. ^ Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters. 508 (2): 201–9. doi:10.1016/s0014-5793(01)02993-3. PMID 11718716. S2CID 21545088.
  15. ^ Weide T, Bayer M, Köster M, Siebrasse JP, Peters R, Barnekow A (Apr 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Reports. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. PMC 1083862. PMID 11306556.
  16. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  17. ^ Joachim J, Jefferies HB, Razi M, Frith D, Snijders AP, Chakravarty P, Judith D, Tooze SA (2015). "Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130". Molecular Cell. 60 (6): 899–913. doi:10.1016/j.molcel.2015.11.018. PMC 4691241. PMID 26687599.

Further reading

Wikimedia Commons has media related to GM130.
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