File:Type II topoisomerase catalytic cycle.png

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Summary

Description
English: Type II topoisomerase strand-passage mechanism. (1) G-segment is bound at the DNA-gate and the T-segment is captured. (2) ATP binding stimulates dimerization of the N-gate, the G-segment is cleaved and the T-segment is passed through the break. (3) The G-segment is re-ligated and the T-segment exits through the C-gate. For type IIB topos, there is no C-gate so once the T-segment passes through the G-segment, it is released from the enzyme. (4) Dissociation of ADP and Pi allows N-gate opening, a scenario where the enzyme either remains bound to the G-segment, ready to capture a successive T-segment, or (5) dissociates from the G-segment.
Date
Source Own work
Author Kcneuman

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Illustration of Type II topoisomerase catalytic cycle

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10 April 2022

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current05:42, 22 June 2022Thumbnail for version as of 05:42, 22 June 20223,341 × 2,864 (1.62 MB)commons>Kcneumancorrected a spelling mistake on the image

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