File:TACG A 178546 O F0001g.jpg

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English: Figure 1 Schematic representation of the classic gene addition protocol for the gene therapy of beta-thalassemia. In brief, Plerixafor+granulocyte-colony stimulating factor (G-CSF) is administered to the patient in order to mobilize hematopoietic stem cells into peripheral blood. Peripheral blood mononuclear cells are then collected with leukapheresis and enriched in CD34+ hematopoietic stem cells. These cells are co-cultured with a viral vector designed to express normal human beta-globin, followed by quality control. Ultimately, the patient is subjected to myelosuppression and then engrafted with the gene-corrected cells.
Date
Source https://www.dovepress.com/gene-therapy-for-beta-thalassemia-updated-perspectives-peer-reviewed-fulltext-article-TACG
Author Karponi G, Zogas N

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