File:Structural domains of the HIV-1 integrase.jpg
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Summary
| Description |
English: Schematic of the domain structure of HIV integrase. Three structural and functional domains have been identified. The N-terminal domain (residues 1-50) contains a HHCC zinc finger motif and is required for dimerization and binding of cellular factors. The catalytic core domain (residues 51-212) contains the conserved residues forming a catalytic triad (D64, D116 and E152) that are required to coordinate essential divalent metal ions (Mn2+ or Mg2+). The C-terminal domain (residues 213-288) binds DNA non-specifically. |
| Date | |
| Source | Own work |
| Author | Hopur3 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 16:18, 20 September 2011 | | 652 × 180 (20 KB) | commons>Hopur3 |
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