File:Serpin activation by heparin (unannotated).png
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Original file (2,400 × 1,131 pixels, file size: 983 KB, MIME type: image/png)
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Summary
| Description |
English: Some serpins are activated by cofactors. The the serpin antithrombin has an RCL (blue) where the P1 arginine (blue sticks) points inwards, preventing protease binding. Binding of heparin (green sticks) causes the P1 arginine residue to flip to an exposed position. The target protease (grey) then binds both the exposed P1 arginine as well as the heparin. The serpin then activates and heparin is released. (PDB: 2ANT, 1TB6, 1EZX) |
| Date | |
| Source | Own work |
| Author | Thomas Shafee |
| Other versions | For annotated version , see File:Serpin activation by heparin.png |
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File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 11:20, 26 December 2015 | | 2,400 × 1,131 (983 KB) | commons>Evolution and evolvability | unstructured RCL loop added |
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