File:PMC4132647 awu175f1p.png

English: awu175-F1: Group functional MRI activation from working memory and group differences. Group functional MRI activation maps from juvenile myoclonic epilepsy siblings and healthy controls. (A–C) Cortical activation for the three different task conditions: motor cortex and supplementary motor area for ‘0 Back’ (A), bilateral frontal and parietal activation for ‘1 minus 0 Back’ and ‘2 minus 0 Back’ (B and C). (D–F) Activation patterns in unaffected juvenile myoclonic epilepsy siblings compared to controls [inclusively masked for task-dependent deactivation maps of healthy controls (P < 0.001 uncorrected; 20 voxel threshold extent)]: no difference for the ‘0 Back’ condition (D), but attenuated deactivation in the motor cortex (E) and the supplementary motor area (F) with increasing task demand in the working memory contrasts was seen.