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Summary
DescriptionMolecular logic of conditional RNAi.png
English: Conditional RNAi (if gene X is transcribed, silence independent gene Y) provides a conceptual framework for exerting spatiotemporal control over gene knockdown. Toward this end, small conditional RNAs (scRNAs) interact and change conformation to transduce between binding of mRNA ‘detection target’ X and production of a Dicer substrate targeting independent mRNA ‘silencing target’ Y. Image from Hochrein et al. 2013; http://pubs.acs.org/doi/abs/10.1021/ja404676x; used with permission of the American Chemical Society.
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