File:Label-free Localisation Microscopy SPDM - Super Resolution Microscopy Christoph Cremer.jpg

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English: First description of 50 nm optical resolution of cellular structures in label-free cells:

Interestingly SPDM revealed cellular objects not detectable under conventional light microscopy

Christoph Cremer, emeritus at Heidelberg university [1]

Comprehensive studies published in Micron, 2010: The paper describes for the first time that optical resolution of cellular structures in the lamda/10 range (about 50 nm) can be achieved even in label-free cells using the localization microscopy SPDM (Spectral Precision Distance/Position Determination Microscopy).

Beside a substantial resolution improvement of autofluorescent structures, SPDM revealed cellular objects with are not detectable under conventional fluorescence imaging conditions.

Rainer Kaufmann, Patrick Müller, Michael Hausmann, Christoph Cremer: Imaging label-free intracellular structures by localisation microscopy. Micron (2010), doi:10.1016/j.micron.2010.03.06
Date
Source Own work
Author Andy Nestl

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  1. ↑ https://www.physik.uni-heidelberg.de/personen/lsf.php?details=1537 |titel=Fakultät für Physik und Astronomie |abruf=2020-10-01

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