File:KRAS protein G12C mutant with GDP and sotorasib 6OIM.png

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Summary

 
This structure was created with PyMOL.
Description Surface model of the KRASG12C mutant oncoprotein (blue) with guanosine diphosphate (orange) and the targeted covalent inhibitor sotorasib (AMG 510, aqua) bound. A magnesium ion (green) is seen towards the upper left, partially obscured by the protein surface.
Created using PyMOL and GIMP. Optimized with OptiPNG.
Date
Source

From PDB entry 6OIM. More information:

  • Canon J, Rex K, Saiki AY, Mohr C, Cooke K, et al. (November 2019). "The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity". Nature 575 (7781): 217–223. DOI:10.1038/s41586-019-1694-1. PMID 31666701.
  • Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, et al. (January 2020). "Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors". J Med Chem 63 (1): 52–65. DOI:10.1021/acs.jmedchem.9b01180. PMID 31820981.
Author Fvasconcellos (talk · contribs)
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Public domain I, the copyright holder of this work, release this work into the public domain. This applies worldwide.
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current20:42, 4 June 2022Thumbnail for version as of 20:42, 4 June 20222,000 × 1,724 (1.42 MB)commons>Fvasconcellos{{Created with PyMOL}} {{Information |Description=Surface model of the {{w|KRAS}}<sup>G12C</sup> mutant oncoprotein (blue) with {{w|guanosine diphosphate}} (orange) and the {{w|targeted covalent inhibitor}} {{w|sotorasib}} ('''AMG 510''', aqua) bound. A magnesium ion (green) is seen towards the upper left, partially obscured by the protein surface.<br>Created using {{w|PyMOL}} and {{w|GIMP}}. Optimized with {{w|OptiPNG}}. |Source= From PDB entry [http://www.rcsb.org/pd...

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