English: Whole genome sequencing analysis of Turkish individuals.

(A) The first two principal components of the Turkish genome dataset combined with 16 individual population subsets from the 1000 Genomes Project dataset. The first and second components explain 6% and 5% of the total variance, respectively.

(B) A population tree based on “Treemix” analysis. The populations included are as follows: Turkey (TUR); Toscani in Italia (TSI); Iberian populations in Spain (IBS); British from England and Scotland (GBR); Finnish from Finland (FIN); Utah residents with Northern and Western European ancestry (CEU); Han Chinese in Beijing, China (CHB); Japanese in Tokyo, Japan (JPT); Han Chinese South (CHS); Yoruba in Ibadan, Nigeria (YRI); Luhya in Webuye, Kenya (LWK). Populations with high degree of admixture (Native American and African American populations) were not included to simplify the analysis. The Yoruban population was used to root the tree. In total four migration events were estimated. The weights for the migration events predicted to originate from the East Asian branch into current-day Turkey was 0.217, from the ancestral Eurasian branch into the Turkey-Tuscan clade was 0.048, from the African branch into Iberia was 0.026, from the Japanese branch into Finland was 0.079.

(C) The first three principal components of the Turkish genome dataset (left panels) and neighbor-joining trees of the 16 subjects (right panels). The upper and lower panels show the same data, except for being colored according to latitude and longitude of subject locations, respectively. The first, second and third principal components each explain ~7% of the total variance.