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English⧼Colon⧽ Ehrlichia entry is coupled with blockade of the activation of the phagocyte NADPH oxidase (NOX2) complex. Extracellular E. chaffeensis uses the C-terminal region of its surface protein EtpE to bind DNase X on the host-cell surface. The consequent lateral redistribution of DNase X within dynamic lipid rafts brings CD147 into association with the EtpE–DNase X complex (1). CD147 relays the signal to downregulate Vav1 GEF (guanine-nucleotide exchange factor; 2A) that prevents Rac1 activation (3A) and consequently prevents activation of the NOX2 complex (4A). CD147 also recruits hnRNP-K to bind N-WASP, leading to activation of N-WASP (conformational change) (2B and 3B). Activated N-WASP binds the Arp2/3 actin-nucleation complex (4B), leading to spatiotemporal actin polymerization and filopodia formation to internalize E. chaffeensis into endosomes (5B). The drawing was modified from (Mohan Kumar et al., 2015), copyright 2015 ASM.