File:DDDT-137783-F01 (cropped).jpg

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DDDT-137783-F01_(cropped).jpg ‎(538 × 337 pixels, file size: 21 KB, MIME type: image/jpeg)

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Summary

Description
English: Figure 1 Mode of action of CDK4/6 inhibitors.

Notes: Palbociclib, ribociclib and abemaciclib inhibit the complex CDK4/cyclin D1, responsible for the phosphorylation and inhibition of the Rb tumor-suppressor gene’s product. When Rb is phosphorylated, the cell proceeds from G1 to Phase S of the cell cycle, replicating DNA and preparing for mitosis.

Abbreviation: Rb, retinoblastoma.
Date
Source https://www.dovepress.com/abemaciclib-a-cdk46-inhibitor-for-the-treatment-of-hrher2-advanced-bre-peer-reviewed-fulltext-article-DDDT
Author Corona SP , Generali D
Other-versions Lua error in Module:Autotranslate at line 77: No fallback page found for autotranslate (base=Extracted from, lang=⧼lang⧽).

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English: This file is licensed CC BY-NC 3.0

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Date/TimeThumbnailDimensionsUserComment
current07:37, 22 March 2024Thumbnail for version as of 07:37, 22 March 2024538 × 337 (21 KB)Doc JamesFile:DDDT-137783-F01.jpg cropped 3 % horizontally, 31 % vertically using CropTool with precise mode.

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