File:Colonic epithelium mouse without tumorigenesis (A) and with tumorigenesis (B). Brown shows 8-oxo-dG.jpg
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_and_with_tumorigenesis_(B)._Brown_shows_8-oxo-dG.jpg){kind=link}
Summary
| Description |
English: Colonic epithelium from a mouse not undergoing colonic tumorigenesis (A), and a mouse that is undergoing colonic tumorigenesis (B). Cell nuclei are stained dark blue with hematoxylin (for nucleic acid) and immunostained brown for 8-oxo-dG. The level of 8-oxo-dG was graded in the nuclei of colonic crypt cells on a scale of 0-4. Mice not undergoing tumorigenesis had crypt 8-oxo-dG at levels 0 to 2 (panel A shows level 1) while mice progressing to colonic tumors had 8-oxo-dG in colonic crypts at levels 3 to 4 (panel B shows level 4) Tumorigenesis was induced by adding deoxycholate to the mouse diet to give a level of deoxycholate in the mouse colon similar to the level in the colon of humans on a high fat diet.[1] The images were made from original photomicrographs. |
| Date | |
| Source | Own work |
| Author | Chaya5260 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 00:12, 19 July 2015 | | 1,200 × 456 (165 KB) | commons>Chaya5260 | User created page with UploadWizard |
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_and_with_tumorigenesis_(B)._Brown_shows_8-oxo-dG.jpg){kind=link}