File:2pf4 pp2a stag.png
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Summary
| Description |
English: The SV40 polyomavirus small tumor antigen (STag) J domain (yellow) and unique region (blue) in complex with the human protein phosphatase 2A (PP2A) A subunit (red), interacting with HEAT repeats 3-7. STag contributes to viral proliferation and cellular transformation in part through its interaction with the host cell PP2A protein. In this interaction the STag protein partially occludes the binding site of the B subunit of PP2A. (Compare File:2iae_pp2a_trimer.png, showing the PP2A trimer.)
Rendered from PDB ID 2PF4. PLoS Biol. 2007 Aug;5(8):e202. Structural basis of PP2A inhibition by small t antigen. Cho US, Morrone S, Sablina AA, Arroyo JD, Hahn WC, Xu W. PMID 17608567. |
| Date | |
| Source | Own work |
| Author | Opabinia regalis |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 03:02, 21 February 2017 | | 1,200 × 800 (517 KB) | commons>Opabinia regalis | {{Information |Description ={{en|1=The SV40 polyomavirus small tumor antigen (STag) J domain (yellow) and unique region (blue) in complex with the human protein phosphatase 2A (PP2A) A subunit (red), interacting with HEAT repeats 3-7. STag contribut... |
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