Cyanobacterial RNA thermometer
| Avashort 5' UTR thermometer | |
|---|---|
 Predicted secondary structure and sequence conservation of PinT small RNA | |
| Identifiers | |
| Rfam | RF02699 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0009266,GO:0045974 |
| SO | SO:0005836,SO:0000204 |
| PDB structures | PDBe |
| Avalong 5' UTR thermometer | |
|---|---|
 Predicted secondary structure and sequence conservation of PinT small RNA | |
| Identifiers | |
| Rfam | RF02698 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0009266,GO:0045974 |
| SO | SO:0005836,SO:0000204 |
| PDB structures | PDBe |
The first cyanobacterial RNA thermometer (RNAT) Hsp17 was found in the 5'UTR of Synechocystis heat shock hsp17 mRNA.[1] Further study demonstrated that cyanobacteria commonly use RNATs to control the translation of their heat shock genes. HspA is a homolog of Hsp17 in thermophilic Thermosynechococcus elongatus. Two more thermometers were found in the 5'UTRs of mesophilic cyanobacteria A. variabilis and Nostoc sp. The first RNAT called avashort was shown to regulate translation by masking the AUG translation start site. The second RNAT called avalong, as it has an extended initial hairpin, might involve tertiary interactions and has similarities to the ROSE element.[2]
References
- ^ Kortmann J, Sczodrok S, Rinnenthal J, Schwalbe H, Narberhaus F (April 2011). "Translation on demand by a simple RNA-based thermosensor". Nucleic Acids Research. 39 (7): 2855–2868. doi:10.1093/nar/gkq1252. PMC 3074152. PMID 21131278.
- ^ Cimdins A, Klinkert B, Aschke-Sonnenborn U, Kaiser FM, Kortmann J, Narberhaus F (2014-01-01). "Translational control of small heat shock genes in mesophilic and thermophilic cyanobacteria by RNA thermometers". RNA Biology. 11 (5): 594–608. doi:10.4161/rna.28648. PMC 4152365. PMID 24755616.
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