Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1gene.[5][6][7]
Function
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.[8][9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (November 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID9806839.
^Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (March 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA and Cell Biology. 16 (3): 281–9. doi:10.1089/dna.1997.16.281. PMID9115637.
Liu Y, Virshup DM, White RL, Hsu LC (November 2002). "Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha". Cancer Research. 62 (22): 6357–61. PMID12438214.
Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, et al. (January 1999). "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene". Genomics. 55 (1): 68–77. doi:10.1006/geno.1998.5610. PMID9889000.
