CD300LB (gene)

CD300LB
Identifiers
Aliases	CD300LB, CD300b, CLM-7, CLM7, CMRF35-A2, IREM-3, IREM3, TREM-5, TREM5, CD300 molecule like family member b
External IDs	OMIM: 610705 MGI: 2685099 HomoloGene: 18374 GeneCards: CD300LB
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.1 Start 74,521,174 bp End 74,531,475 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 114,813,607 bp End 114,825,212 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood appendix bone marrow cells gallbladder spleen right lung smooth muscle tissue upper lobe of left lung rectum Top expressed in blood calvaria spleen sciatic nerve esophagus skin of abdomen white adipose tissue right lung lobe temporal muscle carotid body More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 124599 217304 Ensembl ENSG00000178789 ENSMUSG00000063193 UniProt A8K4G0 Q3U497 RefSeq (mRNA) NM_174892 NM_001037138 NM_199221 NM_001347651 RefSeq (protein) NP_777552 NP_001334580 NP_954691 Location (UCSC) Chr 17: 74.52 – 74.53 Mb Chr 11: 114.81 – 114.83 Mb PubMed search
Wikidata
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CD300 molecule like family member b is a protein that in humans is encoded by the CD300LB gene.

Function

CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008].

Further reading

• Martínez-Barriocanal A, Sayós J (September 2006). "Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways". J. Immunol. 177 (5): 2819–30. doi:10.4049/jimmunol.177.5.2819. PMID 16920917.
• Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y, Shibata F, Yamazaki S, Kumagai H, Nakajima H, Maeda-Yamamoto M, Tybulewicz VL, Takai T, Kitamura T (January 2008). "Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells". Blood. 111 (2): 688–98. doi:10.1182/blood-2007-04-085787. PMID 17928527.
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Gasiorowski RE, Ju X, Hart DN, Clark GJ (January 2013). "CD300 molecule regulation of human dendritic cell functions". Immunol. Lett. 149 (1–2): 93–100. doi:10.1016/j.imlet.2012.10.005. PMID 23072861.
• Voss OH, Murakami Y, Pena MY, Lee HN, Tian L, Margulies DH, Street JM, Yuen PS, Qi CF, Krzewski K, Coligan JE (June 2016). "Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock". Immunity. 44 (6): 1365–78. doi:10.1016/j.immuni.2016.05.005. PMC 4917413. PMID 27261276.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.