Sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
| sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.170 | ||||||||
| CAS no. | 71822-23-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) is an enzyme that catalyzes the chemical reaction
- 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NAD(P)H
The 3 substrates of this enzyme are 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate, NAD+, and NADP+, whereas its 4 products are 4alpha-methyl-5alpha-cholest-7-en-3-one, CO2, NADH, and NADPH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating). Other names in common use include 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase, (decarboxylating), 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, and sterol 4alpha-carboxylic decarboxylase. This enzyme participates in biosynthesis of steroids.
References
- Brady DR, Crowder RD, Hayes WJ (1980). "Mixed function oxidases in sterol metabolism. Source of reducing equivalents". J. Biol. Chem. 255 (22): 10624–9. PMID 7430141.
- Rahimtula AD, Gaylor JL (1972). "Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase". J. Biol. Chem. 247 (1): 9–15. PMID 4401584.
