11-Dehydrothromboxane B2

From WikiProjectMed
(Redirected from 11-dehydrothromboxane B2)
Jump to navigation Jump to search
11-Dehydrothromboxane B2
Names
Preferred IUPAC name
(5Z)-7-{(2R,3S,4S)-4-Hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-6-oxooxan-3-yl}hept-5-enoic acid
Other names
11-Dehydro-thromboxane B2
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
KEGG
UNII
  • InChI=1S/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1 checkY
    Key: KJYIVXDPWBUJBQ-UHHGALCXSA-N checkY
  • InChI=1/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1
    Key: KJYIVXDPWBUJBQ-UHHGALCXBE
  • O=C1O[C@H](/C=C/[C@@H](O)CCCCC)[C@H]([C@@H](O)C1)C\C=C/CCCC(=O)O
Properties
C20H32O6
Molar mass 368.46
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

11-Dehydrothromboxane B2 (or 11-dehydro-TXB2) is produced from the breakdown of thromboxane A2. It is released by activated platelets and urine levels of 11-dehydro-TXB2 can be used to monitor the response to aspirin therapy when used to prevent heart disease[1] and in diseases where platelet activation is prominent.[2]

References

  1. ^ Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG (2007). "A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease". Eur Heart J. 28 (14): 1702–1708. doi:10.1093/eurheartj/ehm226. PMID 17569678.
  2. ^ Catella F, Healy D, Lawson JA, FitzGerald GA (1986). "11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation". PNAS. 83 (16): 5861–5865. Bibcode:1986PNAS...83.5861C. doi:10.1073/pnas.83.16.5861. PMC 386396. PMID 3461463.
Retrieved from "https://mdwiki.org/wiki/11-Dehydrothromboxane_B2"